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Evaluation of focal cerebral ischemia by NMR and histochemistry.

Evaluation of focal cerebral ischemia by NMR and histochemistry.
通过核磁共振和组织化学评估局灶性脑缺血。
批准号:
09470327
负责人:
ARAI Toshiyuki
金额:
$8.32万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
1997
资助国家:
日本
项目状态:
已结题
起止时间:
1997 至 1998

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中文摘要
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英文摘要
Effects of neroprotective drugs on cerebral ischemia were evaluated in animals using nuclear magnetic resonance (NMR) and immunohistochemical analyses.1) Focal cerebral ischemia was introduced in spontaneously hypertensive rats (STIR) using a method of intraluminal vascular occlusion. Then, lactate produced in the damaged area was detected by ^1H NMR.spectroscopy. The increase in lactate was larger in transient ischemia than that in permanent one. The increase in lactate in transient ischemia was attenuated by alpha-phenyl-N-tert- butyl nitrone (PBN), a superoxide scavenger.2) Expression of interleukin-1 receptor antagonist (IL- lra) was investigated in rat brain following transient focal cerebral ischemia induced by 30 min of middle cerebral artery occlusion. The expression of IL-lra was observed on the margin of the neuronal damage 1 day after operation, which was enhanced 4 days after operation and withdrawn 7 days after operation.3) Neuroprotective effects of PBN and oxypurinol, a xanthine oxidase inhibitor, were examined in gerbil global brain .ischemia. Ischemic neuronal damage were evaluated one week after a 3.5 mm bilateral carotid artery occlusion by a histochemical analysis (cresyl violet staining). PBN administered 30 min after ischemia partially attenuated the neuronal damage, while oxypurinol did not.These results indicated that the drug effects on focal cerebral ischemia were precisely evaluated using NMR and immunohistochemical analyses.
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会议论文
Mori H, Arai T, et al.: "Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia : comparison with those of α-phenyl-N-tert-butyl nitrone" Neurosci Lett. 241. 99-102 (1998)
Mori H、Arai T 等人:“蝶呤-6-醛对沙鼠全脑缺血的神经保护作用:与 α-苯基-N-叔丁基硝酮的比较” Neurosci Lett. 241. 99-102 (1998) )
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通讯作者:
Arai T,Mori H,Ishii H,Suzuki T,Kojima S,Mori K: "Auto-oxidation of 5,6,7,8-tetrahydroneopterin" Pteridines. 9. 26-28 (1998)
Arai T、Mori H、Ishii H、Suzuki T、Kojima S、Mori K:“5,6,7,8-四氢蝶呤的自动氧化”蝶啶。
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Arai T,Mori H^*,et al.: "Auto-oxidation of 5,6,7,8-tetrahydroneopterin." Pteridines. 9. 26-28 (1998)
Arai T、Mori H^* 等人:“5,6,7,8-四氢新蝶呤的自动氧化。”
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通讯作者:
Mori H, Arai T^*, et al.: "Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia : comparison with those of a-phenyl-N-tert-butyl nitrone." Neurosci Lrtt. (in press). (1998)
Mori H、Arai T^* 等人:“蝶呤-6-醛对沙鼠全脑缺血的神经保护作用:与 a-苯基-N-叔丁基硝酮的比较。”
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作者: []
通讯作者:
18
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