THE EFFECT OF INFLAMMATORY CYTOKINE AND APOPTOSIS ON PATHOGENESIS OF RSV INFECTION OF CHILDREN
炎症细胞因子和细胞凋亡对儿童RSV感染发病机制的影响
基本信息
- 批准号:07670882
- 负责人:
- 金额:$ 1.22万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1996
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1) The cytokine (IL-6 and TNF-alpha) activity in nasopharyngeal secretions of infants and children with primary respiratory. syncytial virus (RSV) infection. IL-6 and TNF-alpha were detectable in 100% and 67% of cases during the course of infection, respectively. Generally, TNF-alpha was high in the acute phase and declined thereafter. IL-6 activity was also highest in the acute phase and declined thereafter in infants younger than 5 months, white in patients older than 5 months, it increased during the course of the disease to peak in the early convalescent phase. The mechanism of induction of cytokines may be differerent for infants and children in diffent age groups.2) The production of IL-6 and TNF-alpha and the expression of their mRNA were studied neonatal (cord blood) and adult blood monocyte-derived macrophages (MDM) after in vitro infection with RSV.Cord blood MDM exhibited production of high levels of IL-6 within 24 hr after infection. Little or no IL-6 production was detected after 24-48 hr and after in vitro stimulation with inactivated virus. Unlike cord blood MDM,adult MDM demonstrated significant activity of IL-6 after 24 hr infection with live RSV and after exposure to the inactivated virus. The pattern of TNF-alpha production by cord blood and adult blood MDM after live RSV infection resembled closely to the pattern of IL-6 production. The profile of mRNA expression was similar to the production of IL-6 or TNF-alpha. Neonatal cells may be less efficinet in inducing IL-6 production after RSV infection.3) Neonatal MDM can quick produce and secrete IL-6 and TNF-alpha after RSV exposure : however, it can not produce IL-12 and IFN-alpha in spite of the significant expression of there mRNA after RSV infection. Pathogenesis of RSV disease in neonates or young infants may be in partly correlated with these pattern of cytokines production.
1)原发性呼吸道疾病婴幼儿鼻咽分泌物中细胞因子(IL-6和TNF-α)活性的研究合胞病毒(RSV)感染。在感染过程中,IL-6和TNF-α分别在100%和67%的病例中可检测到。一般来说,TNF-α在急性期较高,随后下降。IL-6活性在急性期也最高,随后在5个月以下的婴儿中下降,在5个月以上的患者中为白色,在疾病过程中升高,在早期恢复期达到峰值。2)研究新生儿(脐血)和成人血单核细胞源性巨噬细胞(MDM)体外感染RSV后IL-6和TNF-α的产生及其mRNA的表达。在24-48小时后和用灭活病毒体外刺激后,检测到很少或没有IL-6产生。与脐带血MDM不同,成人MDM在用活RSV感染24小时后和暴露于灭活病毒后表现出显著的IL-6活性。活RSV感染后脐带血和成人血液MDM产生TNF-α的模式与IL-6产生的模式非常相似。mRNA表达谱与IL-6或TNF-α的产生相似。3)新生期MDM在RSV感染后能快速产生和分泌IL-6和TNF-α,但不能产生IL-12和IFN-α,尽管RSV感染后IL-12和IFN-α mRNA表达显著增加。新生儿或小婴儿RSV疾病的发病机制可能与这些细胞因子产生模式部分相关。
项目成果
期刊论文数量(13)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Matsuda K et al: "Development of Interleukin 6 and Tumor Necrosis Factor Alpha Activity in Masopharyngeal Secretions of Infants and Children during Infection with Respiratory Syncytial Virus" Clinical and Diagnostic Laboratory Immunology. 2. 322-324 (1995
Matsuda K 等人:“呼吸道合胞病毒感染期间婴儿和儿童乳咽分泌物中白细胞介素 6 和肿瘤坏死因子 α 活性的发展”临床和诊断实验室免疫学。
- DOI:
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- 影响因子:0
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- 通讯作者:
Matsuda K.et al: "Characteristics of IL-6 and INF-α 〜" J Med Virol. 48. 199-203 (1996)
Matsuda K. 等:“IL-6 和 INF-α 的特性 ~”J Med Virol. 48. 199-203 (1996)
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Tsutsumi H.et al: "RSV bronchiolitis in a girl undergoing 〜" Pediatr Infect Dis J. 15. 635-636 (1996)
Tsutsumi H.et al:“女孩经历 RSV 细支气管炎 ~”Pediatr Infect Dis J. 15. 635-636 (1996)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Matsuda K,Tsutsumi H,Sone S,Yoto Y,Oya K,Okamoto Y,Ogra PL,Chiba S.: "Characteristics of IL-6 and TNF-alpha production by respiratory syncytial virus-infected macrophages in the neonate." J Med Virol. 48. 199-203 (1996)
Matsuda K、Tsutsumi H、Sone S、Yoto Y、Oya K、Okamoto Y、Ogra PL、Chiba S.:“新生儿呼吸道合胞病毒感染的巨噬细胞产生 IL-6 和 TNF-α 的特征。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Tsutsumi H,Matsuda K,Sone S,Takeuchi R.Chiba S.: "Respiratory syncytial virus-induced cytokine production by neonatal macrophages." Clin Exp Immunol. 106. 442-446 (1996)
Tsutsumi H、Matsuda K、Sone S、Takeuchi R.Chiba S.:“呼吸道合胞病毒诱导新生儿巨噬细胞产生细胞因子。”
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- 影响因子:0
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TSUTSUMI Hiroyuki其他文献
TSUTSUMI Hiroyuki的其他文献
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