Genetic variability of human cytomegalovirus UL97 gene which associated with resistance to ganciclovir

人巨细胞病毒UL97基因的遗传变异与更昔洛韦耐药相关

• 批准号: 21591392
• 负责人: TSUTSUMI Hiroyuki
• 金额: $ 1.83万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591392/
• 关键词: ヒトサイトメガロウイルス; UL97遺伝子; ガンシクロビル; CMV; 分子疫学; UL97; 免疫不全; サイトメガロウイルス

UL97 codons 439 to 645 from 61 CMV isolates from 61 immunocompetent Japanese infants and children were sequenced directly. No known GCV resistance mutations were found, meaning that the UL97 mutation had resulted from the use of GCV. On the other hand, a mutation at codon 605(D to E) was frequently identified(56/61 : 91. 8%). This could be a genetic marker for HCMV in East Asian counties, because of its low prevalence in the strains of HCMV circulating in Western countries.

对61例日本婴幼儿CMV分离株UL97密码子第439~645位密码子进行直接测序。没有发现已知的GCV耐药突变，这意味着UL97突变是由使用GCV引起的。另一方面，密码子605(D到E)的突变经常被发现(56/61：91)。8%)。这可能是东亚地区人巨细胞病毒的一个遗传标记，因为它在西方国家流行的巨细胞病毒株中的流行率很低。

项目成果

Successful treatment of refractory Langerhans cell histiocytosis with pulmonary aspergillosis by reduced-intensity conditioning cord blood transplantation.

通过降低强度调理脐带血移植成功治疗难治性朗格汉斯细胞组织细胞增多症合并肺曲霉病。

• 发表时间: 2010
• 期刊: Peditr Transplant
• 作者: Hatakeyama N;Hori T;et al.
• 通讯作者: et al.

Phylogenetic and computational structural analysis of VP7 gene of group a human rotavirus G1P[8] strains obtained in Sapporo, Japan from 1987-to 2000

1987-2000年日本札幌获得的a组人轮状病毒G1P[8]株VP7基因的系统发育和计算结构分析

• DOI: 10.1002/jmv.23247
• 发表时间: 2012
• 期刊: J Med Virol
• 影响因子: 12.7
• 作者: Nagakoka Y;Tatsumi M;et al
• 通讯作者: et al

Phylogenetic and computational structural analysis of VP7 gene of group a human rotavirus G1P[8] strains obtained in Sapporo

札幌获得的a组人轮状病毒G1P[8]株VP7基因的系统发育和计算结构分析

• 发表时间: 2012
• 期刊: J Med Virol
• 影响因子: 12.7
• 作者: Nagaoka Y;Tatsumi M;Tsugawa T;Yoto Y;Tsutsumi H
• 通讯作者: Tsutsumi H

Full sequence analysis of the original Sapporo virus

• DOI: 10.1111/j.1348-0421.2011.00358.x
• 发表时间: 2011-09-01
• 期刊: MICROBIOLOGY AND IMMUNOLOGY
• 影响因子: 2.6
• 作者: Nakanishi, Kaori;Tatsumi, Masatoshi;Tsutsumi, Hiroyuki
• 通讯作者: Tsutsumi, Hiroyuki

Clinical characteristsics and computed tomography findings in children with 2009 pandemic influenza A(H1N1) viral pneumonia.

2009 年大流行甲型 H1N1 流感病毒性肺炎儿童的临床特征和计算机断层扫描结果。

• 发表时间: 2011
• 期刊: Scand J Infect Dis
• 作者: Mori T;Morii M;Terada K;et al.
• 通讯作者: et al.