Understanding the diverse biology of CD4+ T cell resident memory

了解 CD4 T 细胞驻留记忆的多样化生物学

• 批准号: DP220103545
• 负责人: Prof William Heath
• 金额: $ 54.38万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-02-10 至 2026-02-09
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103545
• 关键词: Understanding; diverse; biology; CD4+; cell

This project aims to examine the biology of CD4 T cell memory in tissues. The previously unappreciated complexity of the CD4 T cell resident memory compartment in the liver will be characterised, focusing on the generation, maintenance and diversity of functions of these cells. Expected outcomes include the generation of fundamental knowledge in the disciplines of cellular biology and immunology, and unique, highly specialised student and personnel training through the interdisciplinary approach utilised, which spans cellular biology, live-imaging and transcriptomic analyses. Expected benefits include influential publications and the import of a novel, specialised technique to Australia through an international collaboration (Germany)

该项目旨在研究组织中CD4 T细胞记忆的生物学。以前未被认识到的复杂性的CD4 T细胞驻留在肝脏中的记忆隔间的特点，集中在这些细胞的功能的产生，维护和多样性。预期成果包括细胞生物学和免疫学学科的基础知识的产生，以及通过跨学科方法的独特，高度专业化的学生和人员培训，该方法涵盖细胞生物学，实时成像和转录组学分析。预期收益包括有影响力的出版物和通过国际合作（德国）向澳大利亚引进一种新的专门技术