Understanding the diverse biology of CD4+ T cell resident memory

本项目旨在研究CD4 T细胞记忆在组织中的生物学作用。CD4 T细胞驻留记忆区在肝脏中以前未被认识到的复杂性将被表征，重点是这些细胞的产生、维持和功能的多样性。预期成果包括细胞生物学和免疫学学科的基础知识的产生，以及通过使用跨学科方法进行独特的，高度专业化的学生和人员培训，该方法涵盖细胞生物学，实时成像和转录组学分析。预期的好处包括有影响力的出版物和通过国际合作向澳大利亚引进一种新颖的专业技术（德国）

This project aims to examine the biology of CD4 T cell memory in tissues. The previously unappreciated complexity of the CD4 T cell resident memory compartment in the liver will be characterised, focusing on the generation, maintenance and diversity of functions of these cells. Expected outcomes include the generation of fundamental knowledge in the disciplines of cellular biology and immunology, and unique, highly specialised student and personnel training through the interdisciplinary approach utilised, which spans cellular biology, live-imaging and transcriptomic analyses. Expected benefits include influential publications and the import of a novel, specialised technique to Australia through an international collaboration (Germany)