Quantitation of intramyocardial vascular volume using synchrotron radiation

使用同步辐射对心肌内血管容量进行定量

• 批准号: 07807073
• 负责人: MORI Hidezo
• 金额: $ 1.34万
• 依托单位: TOKAI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07807073/
• 关键词: Synchrotron Radiation; x-ray fluorescence; micro-angiography; microspheres; coronary artery; マイクロスクェア-; マイクロスフェア-; 微小血管; 心筋

We developed an synchrotron radiation excited-x-ray fluorescent system to quantify heavy element (Br or Zr) activity of polystirene microspheres with a dimeter of 15 or 60 mum. By suing this system we evaluated distribution of intramyocardial vessel volume in 10 anesthetized dogs. The intramyocardial vessles were filled witha large amount of microspheres and the the myocardium was cut inot slices with a 20 mum to 2 mm thickness. Two dimensional mapping of local myocardial x-ray fluroescence was performed with a 20.5 keV synchrotron radiation beam (6-500 mum x 6-500 mum). Correlation of local x-ray fluorescence with compton and elastic scattering intensity gave us an index of the relative distribution of intramyocardial vessel volume. We validated the method by comparing the two-dimensional computer graphic images to microscopic images and micro-angiographic images using monochromatic synchrotron radiation as an x-ray source. The present metho demonstrated and uneveness in intramyocaridal vessel volume across the myocardial layrs

我们开发了一种同步辐射激发x射线荧光系统，用于定量直径为15或60微米的聚苯乙烯微球的重元素（Br或Zr）活性。应用该系统对10只麻醉犬的心内血管容量分布进行了评价。心内血管内填充大量微球，将心肌切成片，厚度为20 ~ 2mm。用20.5 keV同步辐射束（6-500 μ m x 6-500 μ m）对局部心肌x射线荧光进行二维成像。局部x射线荧光与康普顿和弹性散射强度的相关性为我们提供了心内血管体积相对分布的指标。我们通过将二维计算机图形图像与使用单色同步辐射作为x射线源的显微图像和微血管造影图像进行比较来验证该方法。本方法显示心肌各层心肌内血管体积的不均匀性

项目成果

H.Mori, et al.: "Modulation of adrenergic coronary vasoconstriction via ATP-sensitive potassium channel." Am J Physiol. 268. H1077-H1085 (1995)

H.Mori 等人：“通过 ATP 敏感钾通道调节肾上腺素能冠状血管收缩。”

H.Mori, et al.: "Small vessle radiography in situ by using monochromatic synchrotron radation." Radiology. 201. 173-177 (1996)

H.Mori 等人：“使用单色同步加速器辐射进行小血管原位放射成像。”

Mori,H et al: "Small vessel rudicgraphy insitu using monochromutic sxnchrotron radiation" Radiology. 201. 173-177 (1996)

Mori,H 等人：“使用单色加速器辐射进行小血管原位成像”放射学。

H,Mori,et al: "Modulation of adrenergic coronary vasoconstriction via ATP-seusitioe polussium channel" American Journal of Physiology. 268. H1077-H1085 (1995)

H，Mori 等人：“通过 ATP-seusitioe polussium 通道调节肾上腺素能冠状血管收缩”美国生理学杂志。

盛英三,他: "放射光による微小血管造影の原理とその応用" 診断と治療. 84・8. 164-169 (1996)

Eizo Mori 等人：“使用同步辐射的微血管造影原理及其应用”诊断和治疗 164-169（1996）。