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Role of T1-201 SPECT in Predicting Treatment Response of Malignant Brain Tumors

T1-201 SPECT 在预测恶性脑肿瘤治疗反应中的作用

基本信息

批准号：
07670981
负责人：
TOMURA Noriaki
金额：
$ 1.54万
依托单位：
AKITA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670981/
关键词：
201T1C1 SPECT Brain Neoplasm Radiotherapy 201T1 エミッションCT

项目摘要

CT and MR imaging have been used as imaging modalities to evaluate therapeutic response of brain tumors, but they are not helpful in accurately assessing response to treatmentimmediately after therapy. Therapeutic response is often identified a few months after therapy. This prospective study attempts to compare T1-201 SPECT with tumor size measued by CT and MR imaging, with emphasis on evaluating therapeutic response before and after radiochemotherapy in patients with brain tumor. Seventeen patients with histologically proved malignant brain tumors underwent T1-201 SPECT before and immediately after radiochemotherapy. On a SPECT imaging, a T1-index was calculated as the ratio of average counts/pixel in the tumor to average counts/pixel in the homologous contralateral brain. To evaluate tumor size, all patients underwent CT and/or MR imaging concurrently with T1-201 SPECT and 2 months after radiochemotherapy. Ratio of T1-index between immediately afte and before therapy, ratio of tumor size between immediately after and before therapy, and ratio of tumor size between 2 months after and before therapy were measured. Correlative studies between SPECT images and tumor size were performed using linearregression analysis for ratio of T1-index and ratio of tumor size. Seven tumors increased in T1-index immediately after therapy, and all of them increased in size 2 months after therapy. Although the ratio of T1-index between immediately after and before therapy did not correlate with the ratio of tumor size between immediately after and before therapy (r=0.33), it correlated with the ratio of tumor size between 2 months after and before therapy (r=0.76, p<.001). Our results suggest that semiquantitative assessment using T1-201 SPECT imaging is useful in predicting tumor response to radiochemotherapy.

CT和MR成像已被用作评估脑肿瘤治疗反应的成像方式，但它们无助于准确评估治疗后立即对治疗的反应。治疗反应通常在治疗后几个月确定。这项前瞻性研究试图将 T1-201 SPECT 与 CT 和 MR 成像测量的肿瘤大小进行比较，重点是评估脑肿瘤患者放化疗前后的治疗反应。 17 名经组织学证实为恶性脑肿瘤的患者在放化疗前和放化疗后立即接受了 T1-201 SPECT。在 SPECT 成像中，T1 指数计算为肿瘤中平均计数/像素与同源对侧大脑中平均计数/像素的比率。为了评估肿瘤大小，所有患者在放化疗后 2 个月与 T1-201 SPECT 同时接受 CT 和/或 MR 成像。测量治疗后与治疗前的T1指数比率、治疗后与治疗前的肿瘤大小比率以及治疗后2个月与治疗前的肿瘤大小比率。使用T1指数比和肿瘤大小比的线性回归分析进行SPECT图像和肿瘤大小之间的相关性研究。七个肿瘤在治疗后立即 T1 指数增加，并且所有肿瘤在治疗 2 个月后尺寸均增加。尽管治疗后和治疗前的 T1 指数比率与治疗后和治疗前的肿瘤大小比率不相关 (r=0.33)，但它与治疗后 2 个月和治疗前的肿瘤大小比率相关 (r=0.76，p<.001)。我们的结果表明，使用 T1-201 SPECT 成像进行半定量评估可用于预测肿瘤对放化疗的反应。