Development of a vascular prosthesis with to angiogenesis

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Basic fibroblast growth factor (bFGF) is one of the strongest angiogenic agent, and affects all cell types involved in would healing. The distribution of bFGF is widespread, because it plays an important role in regulating cell proliferation and mitosis. Angiogenesis by bFGF is important for endothelialization in vascullar prostheses and is significant fro mshortly after implantation. Lack of angiogenic factors in the vascular graft wall may cause for unhealing neointima. Antithrombogenicity is important when the speed of blood is slow in the venous position for satisfactory patency. Natural and permanent antithrombogenicity due to host endothelial cells should be excellent for long-term patency. Accerelated endothelialization on the lumen of vascular prosthesis is important from shortly after implantation. We hypothesized that tissue-fragmented (TF-) grafts are rich of angiogenic activity from shortly after implantation and it ability may work for endothelialization. We developed a TF-graft and observed the healing process including angiogenesis and endothelialozation. Proliferation and mitosis of endothelial cells ware active in the graft wall in the arterial position 5 days after implantation. The full thickness of the intima was organized at 7 days. These results demonstrated that endogenous bFGF is important for endothelialization due to angiogenesis in fabric vascular prostheses, whereas thrombus and infection might have a negative effect. It might be possible to have patent grafts in the venous position, if we could produce stronger antithrombogenicity for a week.