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STUDY ON APPLICATION OF BONE MORPHOGENETIC PROTEIN/FIBROUS GLASS MEMBRANE TO DIRECT PULP CUPPING

骨形态发生蛋白/玻璃纤维膜在直接拔罐中的应用研究

基本信息

批准号：
07672085
负责人：
MATSUDA Koichi
金额：
$ 1.47万
依托单位：
HEALTH SCIENCES UNIVERSITY OF HOKKAIDO
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

Recently, we have advanced age society in Japan, and people recognize that occlusion and mastication are one of fundamental and important function to maintain and promote human health. Conserving dental pulp leads to maintain of tooth and function of occlusion for a long time. Direct pulp cupping and vital pulp amputation have been applied as pulp conservation therapy. Conventionally calcium hydroxide has been used for direct pulp cupping and vital pulp amputation. But, side effect caused by strong stimulation of calcium hydroxide is feared. Therefore, development of new materials which have bio-afinity and function such as promotion of calcification is required.Bone morphogenetic protein (BMP) exists in hard tissues, and is one of growth and differentiation factors that induces cartilage or bone formation. Due to its strong bio-activity, clinical application of BMP in many fields is anticipated.In this study, I did fundamental study on BMP-induced secondary dentin formation. First, we found that fibrous glass membrane is an excellent carrier of BMP in the experiment using animals. Next, we found that phosphophoryn plays an important role in dentinogenesis, and phosphate group is essential for mineral induction. However, co-operation of phosphate group and carboxyl group is very important for mineral induction in dentin matrix when dentin is demineralized. Furthermore, stabilization of dentin collagen increases the ability of mineral induction by phosphophaoryn in dentin.

近年来，随着日本进入老龄化社会，人们认识到咬合和咀嚼是维持和促进人体健康的一项基本而重要的功能。保存牙髓可使牙齿和咬合功能得以长期保持。直接拔髓和活髓切断术已被应用于牙髓保存治疗。传统上氢氧化钙已被用于直接拔髓和活髓切断。但是，氢氧化钙的强烈刺激引起的副作用是令人担忧的。骨形态发生蛋白（BMP）存在于硬组织中，是诱导软骨或骨形成的生长和分化因子之一。BMP具有很强的生物活性，在临床上有着广泛的应用前景。首先，我们在动物实验中发现玻璃纤维膜是BMP的良好载体。接下来，我们发现磷酸化蛋白在牙本质形成中起着重要作用，磷酸基团是矿物质诱导所必需的。然而，磷酸基和羧基的协同作用对于脱矿时牙本质基质中的矿物质诱导非常重要。此外，牙本质胶原的稳定性增加了牙本质中磷酸化蛋白诱导矿物质的能力。