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Effect of site selective cAMP & its metabolite on human adenocarucinoma cell line

Effect of site selective cAMP & its metabolite on human adenocarucinoma cell line
位点选择性 cAMP 的作用
批准号：
07672177
负责人：
YOSHIDA Hideo
金额：
$1.41万
依托单位：
University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
项目状态：
已结题
起止时间：
1995 至 1996
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672177/
关键词：
8-chloro-aenosine 3' : 5'-monophosphate (8-Cl-cAMP)8-chloro-adensinehuman adenocarcinoma cell linecAMP-dependent protein kinase (PKA)cell proliferation

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中文摘要
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英文摘要
We examined the effects of 8-chloro-adenosine 3' : 5'-monophosphate (8-Cl-cAMP), site-selective analogue of cAMP,and its metabolite 8-chloro-adenosine (8-Cl-ad) on the proliferation of human adenocarcinoma cell line HSG cells and its derivative cell line HSG-AZA1, HSG-AZA3, and human adenoid squamou carcinoma cell line TYS cells in culture. Cultivation of these cells in thepresence of 8-Cl-cAMP (0.5muM) or 8-Cl-ad (lmuM) resulted in the growth inhibition and reduction of colony formation rates on plastic surface or in soft agar to under 10%. Whereas the morphological alteration of treated cells were not shown. Then, it was confirmed that the HSG cells treated with 8-Cl-cAMP (0.5muM) or 8-Cl-ad (1muM) were not induced apoptosis, because DNA pattern was similar to untreated cells in agar gel electrophoresis. In addition, the cAMP-dependent protein kinase A,isolated from treated HSG cells, were decreased.
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会议论文
Sato M,Iga H,Yoshioka N and Yoshida H.: "Induction of differentiation into osteoblasts by treatment with 22-oxa-la,25-dihydroxyvitamin D3 in human salivary cancer cells." Differentiation Therapy.Challenges of Modern Medicine.10,. 329-333 (1995)
Sato M、Iga H、Yoshioka N 和 Yoshida H.：“用 22-oxa-la,25-二羟基维生素 D3 处理人唾液癌细胞，诱导分化为成骨细胞。”
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Sato M,Harada K,Bando T,Shirakami T,Nakashiro K,Yoshida H,Nakai S,Kawai K and Adachi M: "Characteristics of antitumor activity of 3,4-dihydro-6-[4- (3,4-dimethoxybenzoyl) -1-piperazinyl]-2 (1H)-quinolinone (vesnarinone) against a human adenoid squamous ca
Sato M、Harada K、Bando T、Shirakami T、Nakashiro K、Yoshida H、Nakai S、Kawai K 和 Adachi M：“3,4-二氢-6-[4-(3,4-二甲氧基苯甲酰基)的抗肿瘤活性特征
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Sato M,Kawamata H,Harada K,Nakashiro K,Ikeda Y,Gohda H,Yoshida H,et al: "Induction of cyclin-dependent kinase inhibitor,p21 by treatment with 3,4-dihydro-6-[4-(3,4)-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone(vesnarinon)in a human salivary cancer c
Sato M、Kawamata H、Harada K、Nakashiro K、Ikeda Y、Gohda H、Yoshida H 等人：“通过 3,4-二氢-6-[4-(3 处理，诱导细胞周期蛋白依赖性激酶抑制剂，p21)
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通讯作者：
Sato M,Kawamata H,Harada K,Nakashiro K,Ikeda Y,Gohda H,Yoshida H,et al: "Induction of cyclin-dependent kinase inhibitor, p21^<KAF:> by treatment with 3,4-dihydro-6-[4-(3,4)-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone(vesnarinon) in a human salivary
Sato M、Kawamata H、Harada K、Nakashiro K、Ikeda Y、Gohda H、Yoshida H 等人：“通过 3,4-二氢-6- 处理诱导细胞周期蛋白依赖性激酶抑制剂，p21^<KAF:>
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