The effect of professional oral health care on improving autoimmune disease

In human gingival cells, Sa3 cells，LPS induced the expression of IL-6 and TNF in dependent of no - B but not PKR. LPS also increased thebinding of PACT to PKR through NF- B pathwayresulting in the phosphorylation of PKR the inactivation of PKR activity caused the up-regulationof IL-6 mRNA表达式in mouse osteoblastic cells， MC3T3-E1 cells. However，it still unclear whether LPS-induced pro-inflammatory cytokines are implicated in the regulation ofPKR activation in Sa3 cells.这些结果suggest that PKR is activated by binding to PACT throughNF- B pathway in iodontitis. On the other handwe compared the value of clinical parameters of periodontal statusthe value of anti-HSP60 salivary IgA and the existence of periodontopathgenic bacteria in salivabetween the rheumatoid group (n=7) and the control group (n=7).没有显著差异观察两个组的存在Campylobacter rectus.这些问题indicated that the measurement of the Campylobacter rectus in saliva might be the important criteriaunder the intervention of professional oral health care。

In human gingival cells, Sa3 cells, LPS induced the expression of IL-6 and TNF・in dependent of NF-・B but not PKR. LPS also increased the binding of PACT to PKR through NF-・B pathway, resulting in the phosphorylation of PKR. The inactivation of PKR activity caused the up-regulation of IL-6 mRNA expression in mouse osteoblastic cells, MC3T3-E1 cells. However, it still unclear whether LPS-induced pro-inflammatory cytokines are implicated in the regulation of PKR activation in Sa3 cells. These results suggest that PKR is activated by binding to PACT through NF-・B pathway in periodontitis. On the other hand, we compared the value of clinical parameters of periodontal status, the value of anti-HSP60 salivary IgA and the existence of periodontopathgenic bacteria in saliva between the rheumatoid group (n=7) and the control group (n=7). No significant difference is observed between two groups except for the existence of Campylobacter rectus. These results indicated that the measurement of the Campylobacter rectus in saliva might be the important criteria under the intervention of professional oral health care.