The effect of professional oral health care on improving autoimmune disease

在人类银杏节细胞、Sa 3细胞、LPS诱导IL-6和TNF的表达·依赖于NF-·B但不是PKR。LPS还增加了PACT与PKR的绑定，通过NF-·B路径，在PKR的磷酸化中的结果。PKR活性的激活导致了小鼠骨弹性细胞、MC 3 T3-E1细胞中IL-6 mRNA表达的上调调节。然而，它仍然不清楚，因为LPS-诱导的前炎症细胞因子在Sa 3细胞中PKR激活的规定中被隐含。这些结果建议PKR是由绑定到PACT激活的，通过NF-·B路径在周期性。在另一方面，我们比较了周期性状态的临床参数的价值、抗HSP 60盐IgA的价值和周期性细菌（n=7）与对照组（n = 7）之间的周期性细菌的存在。没有明显的差异是在两个群体之间观察到的，除了弯曲杆菌的存在。这些结果表明，在Saliva中，对Campylobacter rectus的测量可能是专业口腔保健干预下的重要标准。

In human gingival cells, Sa3 cells, LPS induced the expression of IL-6 and TNF・in dependent of NF-・B but not PKR. LPS also increased the binding of PACT to PKR through NF-・B pathway, resulting in the phosphorylation of PKR. The inactivation of PKR activity caused the up-regulation of IL-6 mRNA expression in mouse osteoblastic cells, MC3T3-E1 cells. However, it still unclear whether LPS-induced pro-inflammatory cytokines are implicated in the regulation of PKR activation in Sa3 cells. These results suggest that PKR is activated by binding to PACT through NF-・B pathway in periodontitis. On the other hand, we compared the value of clinical parameters of periodontal status, the value of anti-HSP60 salivary IgA and the existence of periodontopathgenic bacteria in saliva between the rheumatoid group (n=7) and the control group (n=7). No significant difference is observed between two groups except for the existence of Campylobacter rectus. These results indicated that the measurement of the Campylobacter rectus in saliva might be the important criteria under the intervention of professional oral health care.