Establishment of a novel therapeutic approach targeting cancer stem cells of neuroblastoma using onclytic virus
Establishment of a novel therapeutic approach targeting cancer stem cells of neuroblastoma using onclytic virus
批准号:
22591976
负责人:
YOSHIDA Hideo
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
肿瘤干细胞具有自我更新和分化的潜能。肿瘤干细胞样细胞可以通过球体培养法获得。比较神经母细胞瘤细胞系IMR 32和sIMR 32(通过球体培养提取的细胞)的化学敏感性。IMR 32对顺铂治疗更敏感。然而,HSV-1的细胞毒性没有差异。
英文摘要
Cancer stem cells have potentials of self-renewal and differentiate. Cancer stem cell-like cells could be extracted through the sphere culture method. Neuroblastoma cell line IMR32 and sIMR32 (cells extracted through sphere culture) were compared for chemosensitivity. IMR32 were more susceptible to cisplatin treatment. However, there was no difference in the cytotoxicity by HSV-1.
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Review of surgical treatment in patients enrolled in the JNBSG high risk neuroblastoma clinical trial (A phase II study of multidisciplinary approach to establish standard treatment for advanced neuroblastoma) A report from Japan Neuroblatoma Study Group
JNBSG高危神经母细胞瘤临床试验(一项多学科方法建立晚期神经母细胞瘤标准治疗的II期研究)患者手术治疗回顾日本神经母细胞瘤研究组的报告
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[菱 木 知 郎, ほ か]
通讯作者:
ほ か
DOI:
10.1016/j.jpedsurg.2010.08.021
发表时间:
2010-12-01
期刊:
JOURNAL OF PEDIATRIC SURGERY
影响因子:
2.4
作者:
[Hishiki, Tomoro, Saito, Takeshi, Yoshida, Hideo]
通讯作者:
Yoshida, Hideo
DOI:
10.1007/s00383-010-2775-2
发表时间:
2011-02-01
期刊:
PEDIATRIC SURGERY INTERNATIONAL
影响因子:
1.8
作者:
[Hishiki, Tomoro, Saito, Takeshi, Yoshida, Hideo]
通讯作者:
Yoshida, Hideo
HDM2 impairs Noxa transcription and affects apoptotic cell death in ap53/p73-dependent manner in neuroblastoma
HDM2 损害神经母细胞瘤中 Noxa 转录并以 ap53/p73 依赖性方式影响细胞凋亡
DOI:
--
发表时间:
2010
期刊:
European J of Cancer
影响因子:
--
作者:
[Shi Y, Kamijo T, et al]
通讯作者:
et al
DOI:
10.1038/onc.2010.383
发表时间:
2011-01-01
期刊:
ONCOGENE
影响因子:
8
作者:
[Takenobu, H., Shimozato, O., Kamijo, T.]
通讯作者:
Kamijo, T.
共 11 条
Control and Enhancement of Successive Reaction of Steam Reforming of Dimethyl Ether in a Pressure Gradient in Micro Nozzle
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批准号:21360096
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.4万
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财政年份:2009
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负责人:YOSHIDA Hideo
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依托单位:
The effect of professional oral health care on improving autoimmune disease
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批准号:20390536
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.81万
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财政年份:2008
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负责人:YOSHIDA Hideo
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依托单位:
Immune system of the intestinal mucosa and effects of probiotics in inflammatorybowel disease
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批准号:18591950
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.95万
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财政年份:2006
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负责人:YOSHIDA Hideo
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依托单位:
Development of the therapy with an intratumoral administration of dendritic cells in combination with radiation or anti-cancer drugs against oral cancer : Application to clinical trial.
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批准号:16592006
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2004
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负责人:YOSHIDA Hideo
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依托单位:
Development of Hybrid Gas Bearing Effectively Stabilized by Water Evaporation from Ultra-Fine Porous Medium
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批准号:15360108
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.13万
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财政年份:2003
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负责人:YOSHIDA Hideo
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依托单位:
The correlation between TGF-b3 and HGF/SF in the process of fusion of secondary palatal shelves
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批准号:13671968
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:2001
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负责人:YOSHIDA Hideo
-
依托单位:
Mixing Control System Using Micro Nozzle of 3D Vortex Generator and Flame holder Aiming at High-Speed Diffusion Combustion
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批准号:12450087
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.66万
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财政年份:2000
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负责人:YOSHIDA Hideo
-
依托单位:
GENE THERAPY FOR NEUROBLASTOMA
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批准号:12671735
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:2000
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负责人:YOSHIDA Hideo
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依托单位:
The role of c-Met oncogene expression in the secondary palate shelves adhesion process.
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批准号:11470397
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$6.66万
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财政年份:1999
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负责人:YOSHIDA Hideo
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依托单位:
Development of Microactuators Using Temperature Dependence of Surface Tension
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批准号:11555058
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
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财政年份:1999
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负责人:YOSHIDA Hideo
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依托单位:
Super-Mixing High-Speed Combustion Enhanced by Unsteady Fuel Injection with Timescale of Micro Shear Layer
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批准号:10650202
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:1998
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负责人:YOSHIDA Hideo
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依托单位:
Development of a new method of gene therapy for head and neck cancer patients by electroporation of plasmid vector
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批准号:09672053
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1997
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负责人:YOSHIDA Hideo
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依托单位:
Effect of site selective cAMP & its metabolite on human adenocarucinoma cell line
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批准号:07672177
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:YOSHIDA Hideo
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依托单位:
Development of High Efficiency Ozone Generation Using Non-equilibirum Plasma Based on Hydrodynamic Instability
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批准号:07650245
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:YOSHIDA Hideo
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依托单位:
Antiumor and Antimetastatic Effects of omega3 Fatty Acids against Tumors
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批准号:05807167
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1993
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负责人:YOSHIDA Hideo
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依托单位:
The experimental chemotherapy on human salivary gland cancer.
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批准号:62570900
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1987
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负责人:YOSHIDA Hideo
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依托单位:
海外基金