Development of new antimicrobial pressure sensitive adhesive polymer for surgical tape

首先，我们关注植物过氧化物酶（POD）的高自由基氧化活性，以合成各种抗菌化合物。以愈创木酚、异丁香酚、阿魏酸、咖啡酸、百里香酚、香芹酚、羟基苯乙烯等酚类化合物为原料，通过POD偶联反应制备了多种抗菌化合物。其中，我们选择了异丁香酚衍生的POD反应产物作为抗菌化合物进行进一步实验。接下来，我们准备了几个用于手术胶带的粘合聚合物原型。我们使用了HPAO、PANTA、PAOB、NITTO等聚合物作为基材粘合聚合物。将POD反应产物与基础聚合物在甲苯中混合，得到涂覆在聚合物载体上的涂料混合物。涂覆后，用干燥箱烘干，去除溶剂。我们检查了药物浓度对其抗菌活性的影响，并澄清了超过10%的药物含量是抗菌活性表达所必需的。实际上，含有20%异丁香酚活性药物的黏附聚合物对金黄色葡萄球菌具有明显的抗菌活性。我们认为异丁香酚POD产品的疏水性是导致其对介质渗透性低的原因，并研究了表面活性剂对胶粘剂聚合物的影响。然而，表面活性剂如Tween 20或Tween 80的加入引起了聚合物的聚集。推测上述现象是由非离子表面活性剂与芳香多价异氰酸交联剂反应引起的。综上所述，PAOB和PANTA是本研究的良好候选基础聚合物。交联剂有待进一步研究。

At first, we paid an attention to high radical oxidizing activity of peroxidase (POD) from plant to synthesize various antimicrobial compounds. We succeeded to prepare several antimicrobial compounds derived from several phenolics such as guaicol, isoeugenol, ferulic acid, caffeic acid, thymol, carvacrol and hydroxystilben via POD coupling reaction. Among them, we chose a POD reaction product derived from isoeugenol as an antimicrobial compound for further experiments. Next, we prepare several prototypes of adhesive polymer for surgical tapes. We used following polymers such as HPAO, PANTA, PAOB, and NITTO for base adhesive polymer. POD reaction products were mixed above base polymer in toluene to be yielded dope mixture for coating onto the polymer supports. After coating, the preparations were dried up by the drying oven to remove solvent. We examined effects of drug concentrations on their antimicrobial activities and clarified that more than 10% of drug content is essential for expression of antimicrobial activity. Actually, adhesive polymer containing 20% of active drug from isoeugenol show an apparent antimicrobial activity against Staphyrococuss aureus. We suggested that hydrophobicity of isoeugenol POD products cause its low permeability to medium and studied effects of surfactant addition into adhesive polymer. However, addition of surfactant such as Tween 20 or Tween 8O caused aggregation of polymer. We guess that above phenomena was caused from reaction between nonionic surfactant and aromatic multivalent isocyanic crosslinker. In conclusion, PAOB and PANTA were good candidates as base polymers for this study. Further investigation about crosslinker should be performed.