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Construction of Cell-Targetting Systems by Artificial Glycoconjugate Polymers

Construction of Cell-Targetting Systems by Artificial Glycoconjugate Polymers
人工糖复合聚合物构建细胞靶向系统
批准号:
08558098
负责人:
KOBAYASHI Kazukiyo
金额:
$4.99万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
1996
资助国家:
日本
项目状态:
已结题
起止时间:
1996 至 1998

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中文摘要
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英文摘要
1. Molecular Design of Artificial Glycoconjugate Polymers(1) A convenient synthetic route has been developed to introduce biologically important, complex oligosaccharides to give the corresponding glycopolymers.(2) Rod-like conformation of amphiphilic glycopolymers in water was determined by means ol small-angle X-ray diffraction.(3) Strong adsorption behaviors of amphiphilic glycopolymers onto hydrophobic surface were analyzed with quartz crystal microbalance.(4) Cluster effect in glyco recognition.2. Applications of Glycopolymers to Materials Biotechnology(I) Inhibition of influenza virus infection.(2) Quantitative detection of galactose transferase by GlcNAc-carrying polymer.(3) Production of antibody by sialyldisaccharide-carrying glycopolymers.(4) limmobilization of low-molecular weight proteins.
期刊论文(39)
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会议论文
K. Matsuura K. Kobayashi: "Helical Stereoregular Artificial Glycoconjugate Polymers Bused on Poly(Phenylacetylene)" Chem. Lett.847-848 (1998)
K. Matsuura K. Kobayashi:“基于聚(苯乙炔)的螺旋立体规则人工糖复合聚合物”化学。
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通讯作者:
K. Matsuura K. Kobayashi: "A Quartz-Crystal Microbalance Study of Adsorption Behaviors of Artificial Glycoconjugate Polymers onto Chemically Modified Gold・・・・" Bull. Chem. Soc. Jpn.71. 2973-2977 (1998)
K. Matsuura K. Kobayashi:“人工糖共轭聚合物在化学改性金上的吸附行为的石英晶体微天平研究”,《化学》杂志,2973-2977。
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通讯作者:
C.Zhuang,K.Kobayashi: "Purification and characterization of a Lectin" Biochim.Biophys.Acta. 1291. 40-44 (1996)
C.Zhuang,K.Kobayashi:“凝集素的纯化和表征”Biochim.Biophys.Acta。
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通讯作者:
K.Kobayashi,C.Tawada: "Artificial Glycogolypeptide Conjugates" Biochim.Biophys.Acta. (印刷中). (1997)
K.Kobayashi, C.Tawada:“人工糖肽缀合物”Biochim.Biophys.Acta(出版中)。
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39
    Development of Glyco-Nanomaterials Tissue Engineering and Infectious Diseases
    • 批准号:
      14350486
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.56万
    • 财政年份:
      2002
    • 负责人:
      KOBAYASHI Kazukiyo
    • 依托单位:
    Development of glyco-cluster materials systems to detect and neutralize pathogenic microorganisms
    • 批准号:
      13558108
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.19万
    • 财政年份:
      2001
    • 负责人:
      KOBAYASHI Kazukiyo
    • 依托单位:
    Molecular design of artificial glycoconjugate polymers and their applications to materials biotechnology
    • 批准号:
      10450352
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.98万
    • 财政年份:
      1998
    • 负责人:
      KOBAYASHI Kazukiyo
    • 依托单位:
    Molecular Design of Glycopolymers Having Biological Recongnition Function via Glycosidation
    • 批准号:
      07455371
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $3.71万
    • 财政年份:
      1995
    • 负责人:
      KOBAYASHI Kazukiyo
    • 依托单位:
    海外基金