Smart, wearable artificial lung system

智能、可穿戴式人工肺系统

• 批准号: 10558842
• 负责人: Joseph Allen Potkay
• 金额: $ 72.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10558842
• 关键词: Acute; Affect; Age; Air; Air Movements; Alkalosis; American; Anesthesia procedures; Animal Model; Animal Testing; Animals; Blood; Carbon Dioxide; Cattle; Cessation of life; Chest; Chronic; Chronic Obstructive Pulmonary Disease; Clinical; Compensation; Computer software; Development; Devices; Disease; Dysbarism; Dyspnea; Engineering; Etiology; Excision; Extracorporeal Circulation; Future; Gases; Goals; Hip region structure; Home; Hour; Human; Hypocapnia; In Vitro; Injury; Life; Lung; Lung Transplantation; Lung diseases; Mechanical ventilation; Metabolic; Methods; Mind; Monitor; Patients; Performance; Physical Rehabilitation; Physical therapy; Physiology; Population; Prosthesis; Pump; Quality of life; Recording of previous events; Recovery; Rehabilitation therapy; Research; Respiratory Failure; Rest; Risk; System; Technology; Testing; Transplantation; United States National Institutes of Health; Ventilator; Volutrauma; Waiting Lists; Water; artificial lung; awake; comorbidity; design; exhaust; first-in-human; healing; improved; in vivo; innovation; laptop; lung injury; miniaturize; miniaturized device; operation; portability; prototype; pulmonary function; respiratory; sensor; sheep model; technology development; wearable device

ABSTRACT Tens of thousands of Americans with end stage lung disease (ESLD) are not candidates for lung transplant and thus are doomed to suffer a long and miserable death from dyspnea, limitation of activity, and eventually total respiratory failure. The long-term goal of this technology-development project is to improve the quality of life of end stage lung disease (ELSD) patients by developing wearable artificial lungs that compensate for the changing metabolic needs of the patient. The objectives of the current proposal are to: 1) develop the smart, wearable artificial lung system; and, 2) evaluate the wearable artificial lung system in acute and chronic animal models. At the completion of this project, we will have a functioning wearable artificial lung system that adjusts CO2 clearance based on patient needs, thereby enabling large changes in patient activity and disease status during rehabilitation and daily life. We will be ready to perform extended animal tests and apply for an IDE for first in human trials.

摘要 数以万计患有终末期肺部疾病(ESLD)的美国人不适合肺移植和 因此，他们注定要经历一段漫长而痛苦的死亡，死于呼吸困难，活动受限，最终完全死亡 呼吸衰竭。这一技术开发项目的长期目标是提高人们的生活质量 终末期肺部疾病(ELSD)患者通过开发可穿戴的人工肺来弥补这种变化 患者的新陈代谢需求。当前提案的目标是：1)开发智能、可穿戴的 2)在急、慢性动物模型中评价可穿戴式人工肺系统。在… 这个项目完成后，我们将拥有一个可以调节二氧化碳的可穿戴式人工肺系统 根据患者需求进行清理，从而使患者的活动和疾病状态在 康复和日常生活。我们将准备好进行扩展的动物试验，并为第一个进入申请IDE 人体试验。