Smart, wearable artificial lung system

摘要 成千上万患有终末期肺病（ESLD）的美国人不是肺移植的候选人， 因此，注定要遭受长期和悲惨的死亡呼吸困难，活动限制，并最终完全 呼吸衰竭这项技术开发项目的长期目标是提高人们的生活质量。 终末期肺病（ELSD）患者通过开发可穿戴的人工肺， 患者的代谢需要。当前提案的目标是：1）开发智能、可穿戴 2）在急性和慢性动物模型中评估可穿戴式人工肺系统。在 这个项目完成后，我们将有一个功能齐全的可穿戴人工肺系统， 根据患者需求进行清除，从而在治疗期间实现患者活动和疾病状态的大幅变化。 康复和日常生活。我们将准备进行扩展的动物试验，并申请IDE， 人体试验

ABSTRACT Tens of thousands of Americans with end stage lung disease (ESLD) are not candidates for lung transplant and thus are doomed to suffer a long and miserable death from dyspnea, limitation of activity, and eventually total respiratory failure. The long-term goal of this technology-development project is to improve the quality of life of end stage lung disease (ELSD) patients by developing wearable artificial lungs that compensate for the changing metabolic needs of the patient. The objectives of the current proposal are to: 1) develop the smart, wearable artificial lung system; and, 2) evaluate the wearable artificial lung system in acute and chronic animal models. At the completion of this project, we will have a functioning wearable artificial lung system that adjusts CO2 clearance based on patient needs, thereby enabling large changes in patient activity and disease status during rehabilitation and daily life. We will be ready to perform extended animal tests and apply for an IDE for first in human trials.