Automated control of artificial lung systems to meet patient metabolic needs

成千上万的美国人和退伍军人患有终末期肺病（ESLD）， 移植，因此注定要遭受长期和悲惨的死亡呼吸困难，活动受限， 最终导致呼吸衰竭该技术开发项目的长期目标是提高 通过开发自动快速的人工肺系统， 补偿患者不断变化的呼吸和代谢需求，从而增加患者健康， 舒适度、活动性以及锻炼和康复的能力。本提案的目标是：1） 开发一种用于人工肺系统的控制系统，该系统具有吹扫气体伺服调节功能，以调节CO2 根据患者需要移除;以及，2）在动物模型中评估控制系统。在完成这项工作后， 项目，我们希望准备好将开发的控制系统与各种人工肺系统集成 和假肢，这将是第一次，使病人在康复期间和日常活动的巨大变化， 生活

Tens of thousands of Americans and Veterans with end stage lung disease (ESLD) are not candidates for lung transplant and thus are doomed to suffer a long and miserable death from dyspnea, limitation of activity, and eventually total respiratory failure. The long-term goal of this technology-development project is to improve rehabilitation from lung disease by developing artificial lung systems that automatically and rapidly compensate for the changing respiratory and metabolic needs of the patient, thereby increasing patient health, comfort, activity, and ability to exercise and rehabilitate. The objectives of the current proposal are to: 1) develop a control system for an artificial lung system featuring sweep gas servoregulation to adjust CO2 removal based on patient need; and, 2) evaluate the control system in animal models. At the completion of this project, we expect to be ready to integrate the developed control system with various artificial lung systems and prostheses that will, for the first time, enable large changes in patient activity during rehabilitation and daily life.