Automated control of artificial lung systems to meet patient metabolic needs

数以万计患有终末期肺部疾病(ESLD)的美国人和退伍军人不适合肺部 因此注定会因呼吸困难、活动受限而遭受漫长而痛苦的死亡，以及 最终导致呼吸完全衰竭。这项技术开发项目的长期目标是改进 通过开发自动和快速的人工肺系统从肺部疾病中康复 补偿患者不断变化的呼吸和代谢需求，从而增加患者的健康， 舒适性、活动性以及锻炼和康复的能力。目前提案的目标是：1) 开发一种具有扫气伺服调节功能的人工肺系统控制系统 根据患者的需要进行切除；以及，2)在动物模型中评估控制系统。在完成这项工作后 项目，我们希望准备好将开发的控制系统与各种人工肺系统集成在一起 以及假体，这将首次使患者在康复期间和日常生活中的活动发生巨大变化 生活。

Tens of thousands of Americans and Veterans with end stage lung disease (ESLD) are not candidates for lung transplant and thus are doomed to suffer a long and miserable death from dyspnea, limitation of activity, and eventually total respiratory failure. The long-term goal of this technology-development project is to improve rehabilitation from lung disease by developing artificial lung systems that automatically and rapidly compensate for the changing respiratory and metabolic needs of the patient, thereby increasing patient health, comfort, activity, and ability to exercise and rehabilitate. The objectives of the current proposal are to: 1) develop a control system for an artificial lung system featuring sweep gas servoregulation to adjust CO2 removal based on patient need; and, 2) evaluate the control system in animal models. At the completion of this project, we expect to be ready to integrate the developed control system with various artificial lung systems and prostheses that will, for the first time, enable large changes in patient activity during rehabilitation and daily life.