Radiation Effects on Hybrid-Type Medical Materials
放射线对混合型医用材料的影响
基本信息
- 批准号:08558100
- 负责人:
- 金额:$ 6.53万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:1996
- 资助国家:日本
- 起止时间:1996 至 1998
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
During the course of the development of biomedical materials, sterilization is essential since a material is contaminated with bacteria. Therefore, the polymeric material must be capable of being sterilized without detriment. Sterilization techniques are categorized as physical or chemical ones. Physical methods include dry heat, steam, and ionizing radiation. Chemical sterilization methods by using ethylene oxide is also used widely. Unfortunately, conventional autoclaving method cannot be used for biomimetic materials because they contain heat-labile bioactive components such as proteins. Ethylene oxide gas fumigation causes a health problem by traces of toxic and carcinogenic gas remaining in the material after treatment. Ionizing radiations are able to kill bacteria without including neither heat nor substances affecting the quality of the materials and our health. Thus the irradiation sterilization, which has already been applied to the medical supplies, should be the final candid … More ate for sterilization of the hybrid-type biomedical materials containing proteins. To apply commercial irradiation sterilization technique to the protein-containing hybrid-type biomadical materials, it is necessary to examine radiation torelance of proteins as well as other components at a standard doze of 25kGy generally used for commercial-scale irradiation. There are very few data available for these purpse until now.In this project, to establish irradiation sterilization method for hybrid-type biomedical materials containing bioactive molecules together with artificial polymers, we examined radiation tolerance with 6OCo gamma-rays. We selected enzymes as a model of proteins. Furthermore, we designed various types of-biomedical polymers as well as hybrid-type materials for biomedical applications. Finally, it is concluded that the commercial irradiation sterilization method is applica ble to decontamination of enzymes under an appropriate condition such as dry or frozen state. Although radiation inactivation of enzymes in the aqueous solution was occurred, it could be depressed by control of the irradiation conditions. It is also concluded that the immobilized enzymesare much more stable than free ones for irradiation. These findings suggest that the irradiation sterilization will be useful for hybrid-type biomedical materials in future. Less
在生物医学材料的开发过程中,灭菌是必不可少的,因为材料被细菌污染。因此,聚合物材料必须能够无损害地被灭菌。灭菌技术分为物理灭菌和化学灭菌。物理方法包括干热、蒸汽和电离辐射。使用环氧乙烷的化学灭菌方法也被广泛使用。然而,由于仿生材料中含有蛋白质等热不稳定的生物活性成分,传统的高压灭菌方法不能用于仿生材料。环氧乙烷气体熏蒸处理后残留在材料中的有毒和致癌气体痕迹会导致健康问题。电离辐射能够杀死细菌,而不包括热量或影响材料质量和我们健康的物质。因此,辐照灭菌作为一种已在医疗用品中得到应用的灭菌方法,应是最后的选择 ...更多信息 用于含蛋白质的混合型生物医用材料的灭菌。为了将商业辐照灭菌技术应用于含蛋白质的混合型生物医学材料,有必要在通常用于商业规模辐照的标准剂量25kGy下检查蛋白质以及其他组分的辐射耐受性。本研究以生物活性分子与人工高分子复合的生物医用材料为研究对象,采用6OCo γ射线对材料进行辐照灭菌,以建立生物医用材料的辐照灭菌方法。我们选择酶作为蛋白质的模型。此外,我们还设计了各种类型的生物医学聚合物以及用于生物医学应用的混合型材料。最后得出结论,商业辐照灭菌方法适用于在干燥或冷冻状态等适当条件下对酶进行去污。虽然在水溶液中的酶的辐射失活发生,它可以通过控制辐射条件抑制。固定化酶的辐射稳定性比游离酶好得多。这些结果表明,辐照灭菌将是有用的混合型生物医学材料在未来。少
项目成果
期刊论文数量(51)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Fujita, S.Horii, H.Taniguchi, R.Lakshimi, S.Renganathan, R.: "Pulse Radiolytic Investigations on the Reaction of the 6-yl Radicals of Uracils with Cu(II)-Amino Acid Complexes" Radiat.Phys.Chem.48(5). 643-649 (1996)
Fujita, S.Horii, H.Taniguchi, R.Lakshimi, S.Renganathan, R.:“尿嘧啶 6-基自由基与 Cu(II)-氨基酸复合物反应的脉冲放射分解研究” Radiat.Phys。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
G.Takada,T.Kawaguchi,J.Sumitani,and M.Arai: "Cloning,Nucleotide Sequence,and Transcriptional Analysis of Aspergillus aculeatus No.F-50 Cellobiohydrolase 1 (cbhl) Gene" J.Ferment.Bioeng.85. 1-9 (1998)
G.Takada、T.Kawaguchi、J.Sumitani 和 M.Arai:“棘孢曲霉 No.F-50 纤维二糖水解酶 1 (cbhl) 基因的克隆、核苷酸序列和转录分析”J.Ferment.Bioeng.85。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
T. Kawaguchi, T. Enoki, S. Tsurumaki J. Sumitani, N. Ueda, T. Ooi, M. Arai: ""Cloning and Sequencung of the cDNA encoding β-glucosidase 1 from Aspergikkus aculeatus"" Gene. 173. 287-288 (1996)
173.287-288(1996)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
M. Oka and T. Hayashi: ""Theoretical Conformational Analysis of Periodic Polypeptides Composed of Repetitive Ala-Pro-Xaa-Yaa Sequence"" Peptide Chem.1995. 469-472 (1996)
M. Oka 和 T. Hayashi:“由重复 Ala-Pro-Xaa-Yaa 序列组成的周期性多肽的理论构象分析”,肽化学,1995 年。
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- 影响因子:0
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- 通讯作者:
Matsuda, Y.Yonezawa, M.and Nishiyama, F.: "PIXE Analysis of Serum of Mice Acquired Radioresistance after X-ray Irradiation of Small Dose (II)" Intern.J.PIXE. 7 (3). 233-240 (1997)
Matsuda, Y.Yonezawa, M. 和 Nishiyama, F.:“小剂量 X 射线照射后获得放射抗性的小鼠血清的 PIXE 分析 (II)” Intern.J.PIXE。
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- 影响因子:0
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HAYASHI Toshio其他文献
HAYASHI Toshio的其他文献
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{{ truncateString('HAYASHI Toshio', 18)}}的其他基金
The regression of atherosclerosis through the regulation of cellular senescence: the possible new therapy for Japanese lifestyle related diseases
通过调节细胞衰老来消退动脉粥样硬化:日本生活方式相关疾病的可能新疗法
- 批准号:
24590881 - 财政年份:2012
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Investigation of the regression of advanced atherosclerosis through the regulation of cellular senescence-custom-made therapy to Japanese elderly-
通过细胞衰老调节来消退晚期动脉粥样硬化的研究——日本老年人的定制疗法
- 批准号:
21590762 - 财政年份:2009
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Geriatric and gerontological approach for asian elderly to prevent their atherosclerotic disease and get successful aging.
针对亚洲老年人的老年病学和老年学方法,以预防动脉粥样硬化疾病并实现成功老龄化。
- 批准号:
20406004 - 财政年份:2008
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Regression of Atherosclerosis by the regulation of nitric oxide and superoxide on vascular endocrinology and vascular aging
通过一氧化氮和超氧化物调节血管内分泌和血管老化来消退动脉粥样硬化
- 批准号:
19591043 - 财政年份:2007
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A Study on Mechanisms of Regional Differences of Side Effects of Hormone Replacement Treatment (HRT)
激素替代治疗(HRT)副作用区域差异机制研究
- 批准号:
16406001 - 财政年份:2004
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Gene Therapy of Combined Nitric Oxide Synthases and Related Enzymes to Achieve Complete Regression of Advanced Atherosclerosis-Combined Regulation of Substrate of the Enzymes, Co-factors, Transcriptional Factors and Intracellular Enzymes-
一氧化氮合成酶及相关酶联合基因治疗,实现晚期动脉粥样硬化的彻底消退-酶底物、辅因子、转录因子和细胞内酶的联合调控-
- 批准号:
13670704 - 财政年份:2001
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Conformational Analysis of Periodic Polypeptides Containing Pro Residue
含Pro残基的周期性多肽的构象分析
- 批准号:
11450373 - 财政年份:1999
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Therapy for Advanced Atherosclerosis by Using Vascular Endocrinological System
血管内分泌系统治疗晚期动脉粥样硬化
- 批准号:
11670672 - 财政年份:1999
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Design of Biodegradable Adhesion Prevention
可生物降解的防粘连设计
- 批准号:
06453221 - 财政年份:1994
- 资助金额:
$ 6.53万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
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