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Design of Biodegradable Adhesion Prevention

可生物降解的防粘连设计

基本信息

批准号：
06453221
负责人：
HAYASHI Toshio
金额：
$ 3.71万
依托单位：
Osaka Prefecture University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

The development of tissue adhesion prevention material has been long awaited in surgery. Tissue adhesion after surgery occasionally causes serious complications. Various studies have been undertaken to develop materials that prevent tissue adhesion. These function as a barrier to enable traumatized tissue to be separated from adjacent tissues during the healing process. These materials should be free from cellular adhesion, should be flexible and tough enough to provide for a tight cover over the traumatized soft tissues, and should be biodegradable and resorbable after the injured tissue is completely regenerated. To fully realize these requirements, natural polymers such as fiberous proteins or polysaccharides, which exist as highly water-adsorbable biomaterials filling interstices of tissues, have been considered to be best suited as basic materials. Synthetic polypeptides and their copolymers which carry hydrophilic components offer potential for enzymatic degradable medical applic … More ations.We have prepared many types of hydrophilic polypeptide membranes which are composed of hydrophilic and hydrophobic amino acid components as models of natural fibrous proteins. These includes ; A-B-A type block copolymers consisting of a hydrophilic polypeptide as the A component and polyisoprene as the B component, copoly (N-hydroxyalkyl-D,L-glutamaine)s, two-component random copolypeptides consisting of N-hydroxyalkyl-L-glutamine and L-alanine, L-leucine, or L-valine, and three-component random copolypeptides consisting of N-hydroxyalkyl-L-glutamine, L-glutamic acid, and L-lysine. Hydrophilic membranes or hydrogels were prepared by using a crosslinking reaction with diamine on the starting membranes. It was commonly shown that the effective crosslink density was proportional to the molar % of diamine in the reaction mixture. The relation between their bulk structure and properties was investigated with regard to the swelling ratio in water, tensile properties, and enzymatic degradation behavior in a pseudo-extracellular fluid (PECF). The tensile properties of the hydrophilic membranes were highly dependent on the swelling ratio in PECF,and on the hydrophobic portions in molecular chains, whose behavior was typical of an elastomer. Biodegradations of these membranes in viro by a protease indicated that the degradation took place in bulk rather than on a surface, and that the rate of degradation was also highly dependent on the swelling ratio of membranes, the hydrophobicity, effective charge density, as well as D,L-comonomer composition, of the side chains of samples. Less

组织防粘连材料的开发一直是外科界期待已久的课题。手术后组织粘连偶尔会引起严重的并发症。已经进行了各种研究来开发防止组织粘连的材料。这些功能作为屏障，使创伤组织在愈合过程中与相邻组织分离。这些材料应不含细胞粘附，应具有足够的柔韧性和坚韧以在创伤软组织上提供紧密的覆盖，并且在损伤组织完全再生后应是可生物降解和可再吸收的。为了充分实现这些要求，天然聚合物如纤维状蛋白质或多糖，其作为填充组织间隙的高度吸水性生物材料存在，被认为最适合作为基础材料。合成多肽及其共聚物携带亲水性组分，为酶降解医疗应用提供了潜力 ...更多信息我们已经制备了许多类型的亲水性多肽膜，其由亲水性和疏水性氨基酸组分组成，作为天然纤维蛋白的模型。其中包括：由作为A组分的亲水性多肽和作为B组分的聚异戊二烯组成的A-B-A型嵌段共聚物，共聚（N-羟烷基-D，L-丙氨酸），由N-羟烷基-L-谷氨酰胺和L-丙氨酸、L-亮氨酸或L-缬氨酸组成的双组分无规共聚肽，和由N-羟烷基-L-谷氨酰胺、L-谷氨酸和L-赖氨酸组成的三组分无规共聚肽。亲水性膜或水凝胶通过使用与起始膜上的二胺的交联反应来制备。通常表明，有效交联密度与反应混合物中二胺的摩尔%成比例。研究了它们的体相结构与性能之间的关系，包括在水中的溶胀率、拉伸性能和在假细胞外液（PECF）中的酶降解行为。亲水性膜的拉伸性能高度依赖于在PECF中的溶胀比，以及分子链中的疏水部分，其行为是典型的弹性体。这些膜在体内的蛋白酶的生物降解表明，降解发生在散装，而不是在表面上，降解速率也高度依赖于膜的溶胀比，疏水性，有效电荷密度，以及D，L-共聚单体组合物，样品的侧链。少