A Study on Mechanisms of Regional Differences of Side Effects of Hormone Replacement Treatment (HRT)

共有1971名绝经后妇女参与了这项为期3年的研究（中国：成都345名，昆明333名，韩国：首尔306名，尼泊尔：加德满都156名，伊朗：德黑兰201名，日本：名古屋629名）。接受激素替代疗法的韩国人占32%，日本人占4%，而其他国家的人则为0%。调查问卷显示，日本人。绝经后的女性希望待在室内，很少运动，除了其他亚洲女性之外，爱好也更少。平均年龄66.77±5.09岁，平均绝经年龄18.22±7.41岁。与报道的数据相比，BMI、WC、收缩压、舒张压和TG的平均水平趋于较高。IDF、NCEP ATPIII、CDS和JPN诊断的met患病率分别为37.34%、27.31%、23.29%和13.65%。IDF-MetS患病率最高，JPN-MetS患病率最低。不同MetS组间脂肪因子水平无明显变化，但CDS MetS组脂联素水平最低，而JPN MetS组TNF - α和IL-6水平最高。脂肪细胞因子可能是连接内脏脂肪积累和动脉粥样硬化疾病的关键因素。tnf α, IL-6)或保护性的(例如。脂联素)的角色。在我们的研究中，脂联素水平在met组明显高于正常组。伴有MetS的PMW与伴有代谢紊乱的PMW之间无显著差异。我们现在像上面那样分析snp。在亚洲国家，几乎所有基因型都表现出相同的模式，但PAI-1、ER - a、eNOS等的SNP模式可能存在一定差异。因此，IDF定义的代谢紊乱最敏感，而JPN和CDS定义的代谢紊乱与冠心病和脂肪细胞因子的变化相关性较好。脂肪细胞因子补充不同的诊断标准可能会赋予代谢综合征的定义更多的含义。本研究将涵盖亚洲绝经后妇女的性格、态度和特异性等方面，并可能揭示亚洲、美洲和欧洲妇女动脉粥样硬化的差异，并可能为我们提供泰勒治疗亚洲老年妇女动脉粥样硬化疾病的线索。少

Total 1971 postmenopausal women participated the study during 3 years (China: Chengdu n=345, Kumming n=333, Korea: Seoul n=306, Nepal: Katmandu n=156, Iran: Teheran n=201, and Japan: Nagoya n=629). Hormone replacement therapy were applied for 32% of Korean participants, 4% of Japanese, however 0% to other country's peoples. Questionnaires revealed that Japanese. postmenopausal women hope stay indoors, rarely enjoy exercises and have fewer hobbies other than other Asian women. The mean age was 66.77±5.09 yrs, and mean years after menopause was 18.22±7.41 yrs. Compared with data reported, the mean levels of BMI, WC, systolic BP, diastolic BP, and TG tended to be higher.The prevalence of MetS diagnosed by IDF, NCEP ATPIII, CDS and JPN criteria were 37.34%, 27.31%, 23.29%, and 13.65%, respectively. IDF-MetS had the highest prevalence, whereas JPN-MetS had the lowest one. Although no significant changes of adipocytokines were found among different MetS groups, CDS MetS group tended to have … More the lowest levels of adiponectin, whereas JPN MetS group tended to have the highest levels of TNF alpha and IL-6.Adipocytokines may be the key factors link visceral adipose accumulation and atherosclerotic diseases, by playing harmful (eg.TNFalpha, IL-6) or protective (eg. adiponectin) roles. In our study, adiponectin levels were revealed to be significant higher in MetS groups than in normal groups. No significant differences were revealed between PMW with MetS and PMW with metabolic disorders.We are now analyzing the SNPs as above. Almost all genotype showed same pattern among asian countries, there may be some difference in the pattern of SNP of PAI-1, ER a, eNOS etc.Conclusively, IDF definition for MetS is the most sensitive one to metabolic disorders, whereas JPN and CDS definitions correlate better with CHD and changes of adipocytokines. The supplementation of different dcriteria with adipocytokines may give more meanings to the definition of metabolic syndrome. This study will cover the area of character, attitude and the specificity of asian postmenopausal women and may reveal the difference of atherosclerosis between Asian, American and European women, and may give us the clue of the taylor made therapy for the atherosclerotic diseases of Asian older female. Less