IDENTIFICATION AND PHYSIOLOGICAL ANALYSIS OF MEDULLA BILATERAL LARGE NEURONS INVOLVED IN MUTUAL INTERACTION OF BILATERALLY PAIRED CIRCADIAN CLOCKS IN INSECTS

昆虫中参与双侧生物钟相互作用的延髓双侧大神经元的鉴定和生理分析

基本信息

  • 批准号:
    08640866
  • 负责人:
  • 金额:
    $ 1.41万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1996
  • 资助国家:
    日本
  • 起止时间:
    1996 至 1997
  • 项目状态:
    已结题

项目摘要

Medulla bilateral large neurons (MBNs) are visual interneurons connecting the bilateral circadian clock sites, i.e., optic medulla regions. There are 26 MBNs in each side and they could be classified into 4 groups according to their morpholoy and receptive fields. In this study, we examined which of the 4 group of MBNs transmitts the clock information necessary for mutual coupling between the clocks and how those neurons encode the clock information. With HPLC-ECD we first examined the biogenic amines which would be involved in the MBNs. In the small tissue including MBN somata, serotonin, dopamine, octopamine and some unknown amines were detected. Since MBNs were not labelled by anti-serotonin andanti-doapmine antibodies, their neurotransmitter may be either octopamine or the unknown amine. Howeer, serotonergic and dopaminergic system may play an important role in the information transmission in MBN system, since the electricl stimulation of MBNs reduces the level of these amines in the contralateral optic lobe.Partial destruction of the compound eye corresponding to the receptive fields of the MBNs revealed that MBN-4s, whose receptive field lies in the dorso-caudal area of the eye, are the most likely candidates for the neuron mediating the clock information necessary for the clock coupling. Their response to light was rather weaker than those other MBNs, but their day-night difference was clearly seen, suggesting that they encode the clock information as the magnitude of their response. Other MBNs also showed day night difference in their responsiveness, although the pattern of their responses and day night change were different with each other. These results suggest that MBN-4 conveys the lighting information on its side to the contralateral clock and that other MBNs also have clock related functions in the cricket circadian system.
延髓双侧大神经元(MBN)是连接双侧昼夜节律钟位点的视觉中间神经元,即,视髓区每侧各有26个MBN,根据形态学和感受野可分为4组。在这项研究中,我们研究了4组MBN中的哪一组传递时钟之间相互耦合所需的时钟信息,以及这些神经元如何编码时钟信息。我们首先用HPLC-ECD检测了MBN中可能涉及的生物胺。在包括MBN胞体在内的小组织中检测到5-羟色胺、多巴胺、章鱼胺和一些未知胺。由于MBN未被抗5-羟色胺和抗多阿丁胺抗体标记,因此它们的神经递质可能是章鱼胺或未知的胺。电刺激MBN可使对侧视叶内多巴胺和多巴胺的含量降低,MBN-4s感受野所在的复眼部分破坏后发现,MBN-4s感受野位于眼的背尾侧,是神经元最可能的候选者,该神经元调节时钟耦合所必需的时钟信息。它们对光的反应比其他MBN弱,但它们的昼夜差异很明显,这表明它们将时钟信息编码为响应的大小。其他MBN的反应性也存在昼夜差异,但其反应性和昼夜变化的模式各不相同。这些结果表明,MBN-4传达的照明信息对侧的时钟和其他MBN也有时钟相关的功能,在板球昼夜节律系统。

项目成果

期刊论文数量(27)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tomioka K, Yukizane M: "A specific area of the compound eye in the cricket Gryllus bimaculatus sends photic information to the circadian pacemaker in the contralateral optic lobe." J.Comp.Physiol.A. 180. 63-70 (1997)
Tomioka K、Yukizane M:“蟋蟀双斑蟋蟀复眼的特定区域向对侧视叶的昼夜节律起搏器发送光信息。”
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    0
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Tomioka K, Yukizane M: "A specific area of teh compound eye in the cricket Gryllus bimaculatus sends photic information to the circadian pacemaker in the contralateral optic lobe." J.Comp.Physiol.A. 180. 63-70 (1997)
Tomioka K、Yukizane M:“蟋蟀双斑蟋蟀复眼的一个特定区域向对侧视叶的昼夜节律起搏器发送光信息。”
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    0
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Tomioka K: "Neural mechanisms for mutual imteractions between optic lobe pacemakers in the cricker.In:Circadian organization and Oscillatory Coupling.(Honma K & Honma S eds)," Hokkaido University Press, 159-172 (1996)
Tomioka K:“蟋蟀中视叶起搏器之间相互影响的神经机制。见:昼夜节律组织和振荡耦合。(Honma K)
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  • 影响因子:
    0
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  • 通讯作者:
Tomioka K, Uwozumi K, Matsumoto N: "Light cycles given during development affect freerunning period of circadian locomotor rthythm of period mutant in Drosophila melanogaster." J.Insect Physiol.43. 297-305 (1997)
Tomioka K、Uwozumi K、Matsumoto N:“发育过程中给予的光周期会影响果蝇周期突变体的昼夜节律运动节律的自由运行期。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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  • 通讯作者:
Abe Y, Ushirogawa H, Tomioka K: "Circadian locomotor rhythm of the cricket Gryllodes sigillatus. I. Localization of the pacemaker and the photoreceptor." Zool.Sci.14. 719-727 (1997)
Abe Y、Ushirokawa H、Tomioka K:“蟋蟀 Gryllodes sigillatus 的昼夜节律。I. 起搏器和光感受器的定位。”
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    0
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TOMIOKA Kenji其他文献

TOMIOKA Kenji的其他文献

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{{ truncateString('TOMIOKA Kenji', 18)}}的其他基金

Molecular oscillatory mechanism of the circadian clock in a hemimetabolous insect
半变态昆虫生物钟的分子振荡机制
  • 批准号:
    15H04400
  • 财政年份:
    2015
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of a method for evaluation of ageing in cerebral neuronal circuit using circadian rhythm as a gauge
开发以昼夜节律为衡量标准的脑神经元回路老化评估方法
  • 批准号:
    23657056
  • 财政年份:
    2011
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Analysis of photic entrainment mchanisms of hemimetabolous insects
半变态昆虫光夹带机制分析
  • 批准号:
    23370033
  • 财政年份:
    2011
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of oscillatory mechanism of the circadian clock and its function in hemimetabolous insects
半变态昆虫生物钟振荡机制及其功能分析
  • 批准号:
    19370029
  • 财政年份:
    2007
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of temperature-sensitive oscillatory system in Drosophila circadian clock mechanism
果蝇生物钟机制中温度敏感振荡系统的分析
  • 批准号:
    13440250
  • 财政年份:
    2001
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
MUTUAL INTERACTION BETWEEN RIGHT AND LEFT CEREBRAL LOBES IN INSECTS : COUPLING MECHANISM BETWEEN THE OPTIC LOBE CIRCADIAN CLOCKS
昆虫左右脑叶之间的相互作用:视叶昼夜节律之间的耦合机制
  • 批准号:
    11168219
  • 财政年份:
    1999
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas (A)
THE MECHANISM OF EXPRESSION OF CIRCADIAN CLOCK RELATED PROTEINS IN AN INSECT OPTIC LOBE
昆虫视神经节律相关蛋白的表达机制
  • 批准号:
    10640667
  • 财政年份:
    1998
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
DEVELOPMENT OF A METHOD FOR LONG TERM OPTICAL RECORDING OF ELECTRICAL ACTIVITY FROM INSECT NEURONS WITH VOLTAGE SENSITIVE DYES
开发一种用电压敏感染料长期光学记录昆虫神经元电活动的方法
  • 批准号:
    07554090
  • 财政年份:
    1995
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Analysis of circadian rhythms of optic lobe visual interneurons in the cricket.
蟋蟀视叶视觉中间神经元的昼夜节律分析。
  • 批准号:
    05640770
  • 财政年份:
    1993
  • 资助金额:
    $ 1.41万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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慢性疼痛和神经炎症的昼夜节律控制:一项从床边到工作台的研究
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针对失学神经发育障碍儿童的客观昼夜节律评估和个体化精准治疗
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    23K14823
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识别与改善社交脆弱老年人相关的昼夜节律成分和生活方式
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睡眠和昼夜节律表型以及与阿片类药物使用障碍治疗结果相关的机制
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研究阿片类激动剂治疗 OUD 患者结果的机制:解开睡眠和昼夜节律对渴望和情绪调节的影响
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