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Analysis of mechanism for enhanced iodine uptake in thyrocytes by interferons

Analysis of mechanism for enhanced iodine uptake in thyrocytes by interferons
干扰素增强甲状腺细胞摄碘的机制分析
批准号:
08671023
负责人:
MISAKI Takashi
金额:
$1.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1996
资助国家:
日本
项目状态:
已结题
起止时间:
1996 至 1998

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中文摘要
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英文摘要
In rat thyroid cell line FRTL5, thyroid stimulating hormone (TSH) stimulated protein kinase C (PKC) measured by binding of phorbol-dibutylate. Interferon (IFN) gamma dose dependently suppressed this stimulation. The suppression was reproduced by non-gamma IFN, and potentiated by tumor necrosis factor. On the other hand, inhibitors of PKC such as staurosporine, H-7, and H-9 stimulated iodine uptake in TSH-deprived FRTL5 cells, additive to IFN-driven enhancement. The 3 PKC inhibitors suppressed TSH stimulation of iodine uptake, while IFN act synergistically with TSH in this regard. The results imply IFN inhibits PKC activity via mechanisms different from that of other inhibitors.
期刊论文(17)
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通讯作者:
御前 隆・笠木 寛治: "甲状腺疾患:各種画像診断の有用性" Mebio. 14. 38-42 (1997)
Takashi Gozen 和 Hiroharu Kasagi:“甲状腺疾病:各种图像诊断的有用性”Mebio 14. 38-42 (1997)。
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御前 隆 他: "放射性ヨード療法の著効例" 免疫腫瘍核医学. 12. 60-61 (1997)
Takashi Gozen 等人:“放射性碘治疗的有效效果示例”免疫肿瘤学核医学。12. 60-61 (1997)
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Miyamoto,S, et al.: "Assessment of thyroid growth stimulatlng activity of immunoglobulins from patients with autoimmune thyroid diseases by cytokinesis arrest assay." European Journal of Endocrinology. 136. 499-507 (1997)
Miyamoto,S 等人:“通过胞质分裂停滞测定评估自身免疫性甲状腺疾病患者免疫球蛋白的甲状腺生长刺激活性。”
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17
    Development of a cross-curricular science education curriculum aimed at solving various problems in real life
    • 批准号:
      18K02931
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2018
    • 负责人:
      MISAKI Takashi
    • 依托单位:
    Development of the support program to the primary school teacher who is not specialized in science and a junior high school science teacher having a weak point domain
    • 批准号:
      26590231
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
      2014
    • 负责人:
      MISAKI Takashi
    • 依托单位:
    Analysis of the secular variation of the interaction between a gatekeeper and end users
    • 批准号:
      23530995
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2011
    • 负责人:
      MISAKI Takashi
    • 依托单位:
    Analysis of communication between the student who played a role as gatekeeper and the student who Waved a role as end user in the science class
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