Amotivational syndrome induced by organic solvent inhalation

吸入有机溶剂诱发的动机丧失综合征

• 批准号: 08671098
• 负责人: FUKUI Kenji
• 金额: $ 1.15万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671098/
• 关键词: Organic solvent; Amotivational syndrome; Hippocampus; Electron microscopy; Neurotoxicity; Behavioral pharmacology; Organic solvent; Electron microscopy; Behavioral pharmacology; 有機溶剤; 神経毒性; 海馬; 電子顕微鏡

We examined changes of the dentate gyrus of the rat hippocampus following 1 or 3 month toluene exposure, using glial fibrillary acidic protein (GFAP) immunocytochemistry, and electron microscopy.In 1 month toluene-treated rats, the number and intensity of of GFAP-immunoreactive (IR) processes were markedly increased, and thick GFAP-IR processes appeared, entering into the granular cell layr. However, no apparent degenerative features were observed. In 3 months toluene-treated rats, some of granular cells showed degenerative features such as swelling of perikarya, the decrease of cell organelles and infusion of adjacent cytoplasmic membrane.These results suggest that the neurotoxic effects of toluene and the protective function of astrocytes are balanced at least for 1 month, but the balance is broken up and results in neurodamages for 3 months exposure.

我们使用神经胶质纤维纤维酸性蛋白（GFAP）免疫细胞化学和电子显微镜。在1个月耐受耐受的大​​鼠中，使用gfap-nopering grognoreair的数量和强度，出现了良好的进程（IR），使用了大鼠 - 免疫性（IR-MunnoreAcir）的进程（ir-ir-nopere），我们使用神经纤维酸性蛋白（GFAP）免疫细胞化学的牙齿酸性蛋白（GFAP），甲酸酸性蛋白（GFAP）的甲状腺甲状腺齿状回的变化。进入颗粒细胞层。但是，未观察到明显的退化特征。在甲苯处理的大鼠的3个月中，一些颗粒细胞显示出退化性特征，例如肿胀，细胞细胞器的减少以及相邻的细胞质膜的输注。这些结果表明，这些甲苯的神经毒性影响至少在1个月内平衡，但在3个月中平衡，并在3个月中平衡。

项目成果

K.Fukui, H.Utsumi, Y.Tamada, T.Nakajima and Y.Ibata: "Selective increase in astrocytic elements in the rat dentate gyrus after chronic toluene exposure studied by GFAP immunocytochemistry and electron microscopy." Neurosci.Lett.203. 85-88 (1996)

K.Fukui、H.Utsumi、Y.Tamada、T.Nakajima 和 Y.Ibata：“通过 GFAP 免疫细胞化学和电子显微镜研究慢性甲苯暴露后大鼠齿状回星形胶质细胞成分的选择性增加。”

K.Fukui: "Morphological survey of neurotoxicity induced by addictive drugs" J.Kyoto.Pref.Univ.Med.106. 531-544 (1997)

K.Fukui：“成瘾药物引起的神经毒性的形态学调查”J.Kyoto.Pref.Univ.Med.106。

松田 幹, 他: "有機溶剤吸引の善" 保健の科学. 39. 838-842 (1997)

Miki Matsuda 等人：“有机溶剂抽吸的好处”健康科学 39. 838-842 (1997)。

松田 幹 他: "有機溶剤吸引の善" 保健の科学. 39. 838-842 (1997)

Miki Matsuda 等人：“有机溶剂抽吸的好处”健康科学 39. 838-842 (1997)。