Amotivational syndrome induced by organic solvent inhalation

吸入有机溶剂诱发的动机丧失综合征

• 批准号: 08671098
• 负责人: FUKUI Kenji
• 金额: $ 1.15万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671098/
• 关键词: Organic solvent; Amotivational syndrome; Hippocampus; Electron microscopy; Neurotoxicity; Behavioral pharmacology; Organic solvent; Electron microscopy; Behavioral pharmacology; 有機溶剤; 神経毒性; 海馬; 電子顕微鏡

We examined changes of the dentate gyrus of the rat hippocampus following 1 or 3 month toluene exposure, using glial fibrillary acidic protein (GFAP) immunocytochemistry, and electron microscopy.In 1 month toluene-treated rats, the number and intensity of of GFAP-immunoreactive (IR) processes were markedly increased, and thick GFAP-IR processes appeared, entering into the granular cell layr. However, no apparent degenerative features were observed. In 3 months toluene-treated rats, some of granular cells showed degenerative features such as swelling of perikarya, the decrease of cell organelles and infusion of adjacent cytoplasmic membrane.These results suggest that the neurotoxic effects of toluene and the protective function of astrocytes are balanced at least for 1 month, but the balance is broken up and results in neurodamages for 3 months exposure.

用胶质细胞酸性蛋白（GFAP）免疫细胞化学和电镜技术观察了甲苯染毒1个月和3个月后大鼠海马齿状回的变化，结果表明：甲苯染毒1个月后，海马齿状回GFAP免疫反应（IR）突起数量和强度明显增加，并出现粗大的GFAP IR突起，进入颗粒细胞层。然而，没有观察到明显的退行性特征。甲苯染毒3个月后，部分颗粒细胞出现胞体肿胀、细胞器减少、胞质膜浸润等退行性改变，提示甲苯的神经毒性作用与星形胶质细胞的保护作用至少在1个月内是平衡的，3个月后平衡被打破，导致神经损伤。

项目成果

K.Fukui, H.Utsumi, Y.Tamada, T.Nakajima and Y.Ibata: "Selective increase in astrocytic elements in the rat dentate gyrus after chronic toluene exposure studied by GFAP immunocytochemistry and electron microscopy." Neurosci.Lett.203. 85-88 (1996)

K.Fukui、H.Utsumi、Y.Tamada、T.Nakajima 和 Y.Ibata：“通过 GFAP 免疫细胞化学和电子显微镜研究慢性甲苯暴露后大鼠齿状回星形胶质细胞成分的选择性增加。”

松田 幹 他: "有機溶剤吸引の善" 保健の科学. 39. 838-842 (1997)

Miki Matsuda 等人：“有机溶剂抽吸的好处”健康科学 39. 838-842 (1997)。

K.Fukui: "Morphological survey of neurotoxicity induced by addictive drugs" J.Kyoto.Pref.Univ.Med.106. 531-544 (1997)

K.Fukui：“成瘾药物引起的神经毒性的形态学调查”J.Kyoto.Pref.Univ.Med.106。

松田 幹, 他: "有機溶剤吸引の善" 保健の科学. 39. 838-842 (1997)

Miki Matsuda 等人：“有机溶剂抽吸的好处”健康科学 39. 838-842 (1997)。