An investigation of neural mechanism of early stage of solvent abuse

溶剂滥用早期神经机制的研究

• 批准号: 23591725
• 负责人: FUKUI Kenji
• 金额: $ 2.41万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591725/
• 关键词: 有機溶剤; MRI; 有機溶剤乱用; 神経画像

This study sought to investigate neural mechanism of formation and maintenance of solvent abuse. We reported a case of solvent abuse who revealed hypofrontality shown by SPECT and frontal dysfunction on neuropsychological tests. We also measured brain activity during reward task using fMRI. We first collected data from healthy subjects to compare with patients. Moreover, we developed new cognitive task that can test performance of patients to relate past experience with current decision making and collected data from normal subjects. These tasks are expected to contribute to reveal the brain mechanism of formation and maintenance of solvent abuse.

本研究旨在探讨溶剂滥用形成和维持的神经机制。我们报告一个滥用溶剂的病例，其SPECT显示出额叶功能减退，而神经心理学测验则显示出额叶功能障碍。我们还使用fMRI测量了奖励任务期间的大脑活动。我们首先收集了健康受试者的数据，与患者进行比较。此外，我们开发了新的认知任务，可以测试患者的表现，将过去的经验与当前的决策和收集的数据，从正常的主题。这些任务有望有助于揭示溶剂滥用形成和维持的脑机制。

项目成果

A tract-based spatial statistics study in anorexia nervosa : abnormality in the fornix and the cerebellum

神经性厌食症基于束的空间统计研究：穹窿和小脑异常

• DOI: 10.1016/j.pnpbp.2014.01.009
• 发表时间: 2014
• 期刊: Prog Neuropsychopharmacol Biol Psychiatry
• 作者: Nagahara Y;Fukui K(他10人)
• 通讯作者: Fukui K(他10人)