Morphological research on amotivational syndrome induced by organic solvent inhalation -its mechanism and treatment-

有机溶剂吸入所致动机丧失综合征的形态学研究-机制及治疗-

• 批准号: 10670912
• 负责人: FUKUI Kenji
• 金额: $ 1.09万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670912/
• 关键词: organic solvent; abuse; neurotoxicity; amotivational syndrome; hippocampus; rat; functional morphology; 形態学; 有機溶剤乱用; 動固喪失症候群; ラット脳; 電子顕微鏡

Using chronic toluene-treated rats as the model of amotivational syndrome in humans, I tried to elucidate the mechanism of the syndrome from the point of morphological approach. Hippocampus that is closely related with emotion and memory was observed by light and electron microscopy after the toluene inhalation.(1)The number of the degenerative granular cell in the hippocampus were counted. The number in the chronic toluene-treated (22.5%) was significantly higher than that of control rat (8.2%).(2)After the inhalation of toluene (3 months), vasoactive and metabolic activating drug was treated for 1 month. Memory function was tested by the passive avoidant behavior method. The retention time in the light room of vasoactive metabolic activating drug-treated rat was longer (155.45±27.36sec) than that of non-treated rat (90.59±10.43sec) significantly.Chronic toluene treatment caused the degeneration in the granular cells in the dentate gyrus of the hippocampus and the treatment of vasoactive metabolic activating drug might improve the degeneration induced by toluene inhalation.

以慢性甲苯处理的大鼠作为人类动机综合征的模型，试图从形态学角度阐明该综合征的发生机制。吸入甲苯后，光镜和电镜观察到与情绪和记忆密切相关的海马区。(1)统计海马退行性颗粒细胞数量。慢性甲苯处理大鼠（22.5%）明显高于对照组（8.2%）。(2)吸入甲苯（3个月）后，给予血管活性及代谢激活药物治疗1个月。采用被动回避行为法测试记忆功能。血管活性代谢激活药物处理大鼠在光室的停留时间（155.45±27.36秒）明显长于未处理大鼠（90.59±10.43秒）。慢性甲苯处理引起海马齿状回颗粒细胞变性，血管活性代谢激活药物治疗可改善甲苯吸入引起的变性。

项目成果

福居 顯二 他: "臨床精神医学講座 第8巻 薬物・アルコール関連障害"中山書店. 436 (1999)

Kenji Fukui 等：《临床精神病学课程第 8 卷药物/酒精相关疾病》Nakayama Shoten 436 (1999)。

Kitabayashi, Y. et al.: "Organic solvent abuse and dependence."Igaku no Ayumi. 193. 692 (2000)

Kitabayashi, Y. 等人：“有机溶剂滥用和依赖。”Igaku no Ayumi。

北林 百合之介 他: "有機溶剤の乱用と依存"医学のあゆみ. 193. 692 (2000)

Yurinosuke Kitabayashi 等人：“有机溶剂的滥用和依赖”医学史 193. 692 (2000)。