Detection of Abnormal Information Processing on Schizophrenic Brain using gamma band EEG

利用伽玛带脑电图检测精神分裂症大脑信息处理异常

• 批准号: 08671120
• 负责人: UCHIDA Sunao
• 金额: $ 1.22万
• 依托单位: Tokyo Institute of Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671120/
• 关键词: Gamma activity; electrocorticogram; electroencephalogram; schizophrenia; information processing; hippocampus; medial temporal lobe; ガンマ波; 40Hz

EEG gamma activity has been draw interests of Neuroscientists since it is considered as a frequency that binds informations in various part of cerebral cortex. However, literature on gamma frequency has been limited to animal literatures, and human gamma oscillation has not been established. In this study, we examine human electrocorticogram obtained from epileptic patients for possible neurosurgical operation. We found 30-150 Hz frequency band is significantly enhanced in medial temporal region compared with basal temporal cortex. Raw EEG data also obtained from this region also showed about 90 Hz regular oscillation.In this region, 10-20 Hz oscillation was also found. In basal temporal cortex and some part of medial temporal lobe, alpha oscillation was also observed. Alpha oscillation was attenuated in by eyes opening. However, 10-20 Hz oscillation was not attenuated by eyes opening. We think this oscillation also plays an important role in information processing.We will further investigate these frequencies using ECoG and EEG.We will also extend subject population from epileptic and normal to endogenous psychiatric disorders.

脑电图伽马活动引起了神经科学家的兴趣，因为它被认为是在大脑皮层各个部分结合信息的频率。然而，有关伽马频率的文献仅限于动物文献，人类伽马振荡尚未建立。在这项研究中，我们检查了从癫痫患者身上获得的人类皮层电图，以进行可能的神经外科手术。我们发现与基底颞叶皮层相比，内侧颞区的 30-150 Hz 频段显着增强。从该区域获得的原始脑电图数据也显示出约 90 Hz 的规则振荡。在该区域中，还发现了 10-20 Hz 的振荡。在基底颞叶皮层和内侧颞叶的某些部分也观察到α振荡。阿尔法振荡因睁眼而减弱。然而，10-20 Hz 振荡并未因眼睛睁开而减弱。我们认为这种振荡在信息处理中也发挥着重要作用。我们将使用 ECoG 和 EEG 进一步研究这些频率。我们还将受试者群体从癫痫和正常人群扩展到内源性精神疾病。

项目成果

S.Uchida,Y.Takizawa,N.Hirai,M.Ishiguro.: "Application of Instantaneous Maximum Entropy Method on human sleep electroencephalogram analysis." IEICE Trans.Fundamentals. E80-A. 965-970 (1997)

S.Uchida，Y.Takizawa，N.Hirai，M.Ishiguro.：“瞬时最大熵方法在人体睡眠脑电图分析中的应用”。

S.Uchida et al.: "Flunitrazepam effects on hwnan sleep EEG Spectra" Life Sciences. 58. PL199-205 (1996)

S.Uchida 等人：“氟硝西泮对 hwnan 睡眠脑电图谱的影响”生命科学。

S.Uchida, T.Maehara, N.Hirai, Y.Okubo, H.Shimizu: "A case of human natural sleep recording with subdural electrodes showed no sigma (12-16 Hz) EEG activity on the orbitofrontal cortex." (abstract). Electroenceph.Clin.Neurophysiol.[in print]. (1998)

S.Uchida、T.Maehara、N.Hirai、Y.Okubo、H.Shimizu：“用硬膜下电极记录人类自然睡眠的一个案例显示，眶额皮层没有西格玛（12-16 Hz）脑电图活动。”

内田 直: "睡眠脳波のコンピュータ解析 -脳波スペクトルの一夜の経時的変化-" 脳波と筋電図. 25(6). 432-436 (1997)

Nao Uchida：“睡眠脑电图的计算机分析 - 一晚脑电图频谱的变化”EEG 和肌电图 25(6) (1997)。

S.Uchida: "Computer analysis of polysomnography" Nippon Rinsho. 56 (2). 593-498 (1998)

S.Uchida：“多导睡眠图的计算机分析”Nippon Rinsho。