IMMUNOHISTOCHEMICAL STUDIES OF AGE-RELATED AND OSTEOARTHRITIC CHANGES IN TEMPOROMANDIBULAR JOINT

本研究从以下两个方面对快速老化小鼠（SAM）和人类颞下颌关节的增龄性和骨关节相关性变化进行了免疫组化研究。与2月龄相比，4月龄SAMP8髁突软骨中，中间区和肥大区I型胶原的沉积减少。II型胶原不仅在肥大区增加，而且在关节和中间区。X型胶原存在于肥大区的细胞周围基质中，并且在中间区弥漫性染色强度增加。HABP存在于整个软骨，并在中间和肥大区减少。在人髁突软骨中，I型胶原主要分布于关节区和中间区。II型胶原蛋白存在于中间和肥大区。IV型胶原蛋白存在于关节和肥大区。X型胶原存在于肥大区的细胞周基质中。HABP分布于软骨的关节区、中间区和肥大区的细胞周围基质

In this study, the following two aspects on the immunohistochemistry of the age-related and osteoarthric changes related with the temporomandibular joint of the Senescence Accelerated Mouse (SAM) and human were researched. In the condylar cartilage at 4 month-old SAMP8 compared with 2 month-old, the syaining of type I collagen decreased in the intermediate and hypertrophic zone. Type II collagen not only increased in the hypertrophic zone but also in the articular and intermediate zones. Type X collagen was present in the pericellular matrix of the hypertrophic zone, and increased stain intensity located diffusely in the intermediate zone. HABP was present throughout the cartilage, and decreased in the intermediate and hypertrophic zones. In the condylar cartilage of human, the stainingof type I collagen was present in the articular and intermediate zones. Type II collagen was present in the intermediate and hypertrophic zones. Type IV collagen was present in the articular and hypertrophic zones. Type X xollagen was present in the pericellular matrix of the hypertrophic zone. HABP was present throughout the articular and intermediate zones of cartilage and the pericellular matrix of the hypertrophic zone