Hormonal control of anti-sperm immune response in hen oviduct

母鸡输卵管抗精子免疫反应的激素控制

• 批准号: 10660272
• 负责人: YOSHIMURA Yukinori
• 金额: $ 0.64万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10660272/
• 关键词: CHICKEN; OVIDUCT; IMMUNE; STEROIDS; RECEPTOR; SPERM; MACROPGAGE; LYMPHOCYTE; 免疫機能; 抗原提示細胞; Tリンパ球; Bリンパ球; 性ステロイド; 加齢; ニワトリ

The goal of this study was to determine the mechanism by which the immune functions in hen oviduct was controlled. Oviductal immune functions are important to protect the birds from infection and affect the sperm survival in the oviduct. In this study, we found receptors for progesterone and estrogen in the sperm storage tubules, suggesting that suppression of anti-sperm immunoresponse in this tissue may be regulated by sex steroids. Also, we have found immunocompetent cells including macrophages, major histocompatibility complex class II, T and B cells in the oviductal mucosal tissues, and their population was increased during sexual maturation. Disorder of their population occurred during aging thereafter. Sex steroids partially increased their population. We conclude that avian oviductal immune functions which are important in defense system and sperm population are affected by sexual maturation, aging, and sex steroids are involved in this mechanism.

本研究的目的是探讨鸡输卵管免疫功能的调控机制。输卵管免疫功能对保护鸟类免受感染和影响精子在输卵管中的存活具有重要作用。在这项研究中，我们在精子储存小管中发现了孕激素和雌激素受体，这表明该组织中抗精子免疫反应的抑制可能受到性类固醇的调节。此外，我们在输卵管粘膜组织中发现了免疫活性细胞，包括巨噬细胞、主要组织相容性复合体II类、T和B细胞，并且它们的数量在性成熟期间增加。在此后的老龄化过程中，他们的人口出现了混乱。性类固醇部分增加了它们的数量。性成熟和衰老影响着禽类输卵管免疫功能，而性激素参与了这一机制。

项目成果

Zheng,WM: "Immunolocalization of progesterone and estrogen receptors in the sperm storage tubules of laying and diethylstilbestrol-injected immature hens"Poultry Science. 79・1. 94-98 (2000)

郑 WM：“蛋鸡和注射己烯雌酚的未成熟母鸡精子储存管中孕酮和雌激素受体的免疫定位”家禽科学 79・1 (2000)。

Zheng. WM and Yoshimura, Y: "Localization of macrophages in the chicken oviduct : effects of age and gonadal steroids."Poultry Sci.. 78. 1014-1018 (1999)

郑。

Yoshimura,Y: "Histological characterization of the oviducal structures in Guinea fowl (Numida meleagris)"Journal Poultry Science. 35・1. 149-156 (1999)

Yoshimura, Y：“珍珠鸡（Numida meleagris）输卵管结构的组织学特征”，《家禽科学》杂志 35・1（1999）。

Yoshimura, Y and Ogawa, H: "Histological characterization of the oviducal structures in Guinea fowl (Numida meleagris)."Jpn. Poult. Sci.. 35. 149-156 (1998)

Yoshimura, Y 和 Okawa, H：“珍珠鸡 (Numida meleagris) 输卵管结构的组织学特征。”Jpn。

Yoshimura,Y.: "Immunolocalization of progesterone and estrogen receptors in the sperm storage tubules of laying and diethylstilbestrol-injected immature hens."Poultry Science. 79・1. 94-98 (2000)

Yoshimura, Y.：“产蛋母鸡和注射己烯雌酚的未成熟母鸡的精子储存管中的黄体酮和雌激素受体的免疫定位”，《家禽科学》79·1。