Studies on the mechanism of antimicrobial peptide synthesis for a strategy to enhance the innate immunity in hen oviduct

抗菌肽合成机制研究增强母鸡输卵管先天免疫策略

• 批准号: 21380174
• 负责人: YOSHIMURA Yukinori
• 金额: $ 9.4万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21380174/
• 关键词: 鳥類; 卵管; 自然免疫; 抗菌ペプチド; 粘膜バリア; 感染防御; サイトカイン; 繁殖; 粘液糖類; 粘液糖鎖

The aim of this study was to determine the host defense functions by innate immune system in the hen oviduct. The results showed the first defense systemwas formed by mucosal barrier with mucin layer and epithelial cell tight junctions, induction of immunoresponse by cytokines, and synthesis of avian β-defensins (AvBDs). Decline of mucosal barrier system in molting birds was likely to be one of the reasons whyinfectious risk increases in them. The current study suggested a new mechanism by which AvBDs are induced, namely IL1β upregulates the expression of some AvBDs.

本研究旨在探讨母鸡输卵管内先天免疫系统对宿主防御功能的影响。结果表明，第一个防御系统是由粘蛋白层与上皮细胞紧密连接的粘膜屏障、细胞因子诱导的免疫应答和禽β-防御素（avbd）的合成形成的。蜕皮鸟类粘膜屏障系统的下降可能是其感染风险增加的原因之一。本研究提出了一种新的诱导avbd的机制，即il - 1β上调部分avbd的表达。

项目成果

Immunolocalization of avian beta-defensins in the hen oviduct and their changes in the uterus during eggshell formation

禽类β防御素在母鸡输卵管中的免疫定位及其在蛋壳形成过程中在子宫中的变化

• 发表时间: 2009
• 期刊: Reproduction
• 影响因子: 3.8
• 作者: Abdel Mageed AM;Isobe N and Yoshimura Y
• 通讯作者: Isobe N and Yoshimura Y

Effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokines and the subsequent recruitment of immunocompetent cells in the oviduct of laying and molting hens

• DOI: 10.3382/ps.2011-01596
• 发表时间: 2011-10-01
• 期刊: POULTRY SCIENCE
• 影响因子: 4.4
• 作者: Nii, T.;Sonoda, Y.;Yoshimura, Y.
• 通讯作者: Yoshimura, Y.

Effects of Repeated Lipopolysaccharide Stimulation on the Development of Antigen-presenting Cells and T Cells Pool in Hen Vagina

• DOI: 10.2141/jpsa.0120086
• 发表时间: 2013-01-01
• 期刊: JOURNAL OF POULTRY SCIENCE
• 影响因子: 1.5
• 作者: Nii, Takahiro;Isobe, Naoki;Yoshimura, Yukinori
• 通讯作者: Yoshimura, Yukinori

Inductions in the recruitment of T cells and expression of chemokines in response to pathogenic agents in the lower oviducts between laying and molting hens.Korea-Japan Joint Symposium on Avian Biology 2011(2011.7.11,ソウル大、韓国)

蛋鸡和麦芽鸡下输卵管中T细胞募集和趋化因子表达的诱导响应病原体。2011年韩日禽生物学联合研讨会（2011年7月11日，首尔国立大学，韩国）

• 发表时间: 2011
• 作者: Nii T;Sonoda Y;Isobe N;Yoshimura Y
• 通讯作者: Yoshimura Y

Differences in the localization and molecular size of glycoproteins forming the mucosal barrier in the lower part of oviduct in laying and molting hens

产蛋鸡和换毛鸡输卵管下部形成粘膜屏障的糖蛋白的定位和分子大小差异

• 发表时间: 2011
• 作者: Bambang Ariyadi;Naoki Isobe;Yukinori Yoshimura
• 通讯作者: Yukinori Yoshimura