Studies on the mechanism of antimicrobial peptide synthesis for a strategy to enhance the innate immunity in hen oviduct

抗菌肽合成机制研究增强母鸡输卵管先天免疫策略

• 批准号: 21380174
• 负责人: YOSHIMURA Yukinori
• 金额: $ 9.4万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21380174/
• 关键词: 鳥類; 卵管; 自然免疫; 抗菌ペプチド; 粘膜バリア; 感染防御; サイトカイン; 繁殖; 粘液糖類; 粘液糖鎖

The aim of this study was to determine the host defense functions by innate immune system in the hen oviduct. The results showed the first defense systemwas formed by mucosal barrier with mucin layer and epithelial cell tight junctions, induction of immunoresponse by cytokines, and synthesis of avian β-defensins (AvBDs). Decline of mucosal barrier system in molting birds was likely to be one of the reasons whyinfectious risk increases in them. The current study suggested a new mechanism by which AvBDs are induced, namely IL1β upregulates the expression of some AvBDs.

这项研究的目的是确定Hen Oviduct中先天免疫系统的宿主防御功能。结果表明，粘膜层和上皮细胞紧密连接，细胞因子对免疫响应的诱导以及合成禽β-屈服（AVBD）形成的第一个防御系统WAS。在摩尔鸟类中，粘膜屏障系统的下降可能是传染风险增加的原因之一。当前的研究提出了一种新的机制，通过诱导AVBD，即IL1β上调某些AVBD的表达。

项目成果

Immunolocalization of avian beta-defensins in the hen oviduct and their changes in the uterus during eggshell formation

禽类β防御素在母鸡输卵管中的免疫定位及其在蛋壳形成过程中在子宫中的变化

• 发表时间: 2009
• 期刊: Reproduction
• 影响因子: 3.8
• 作者: Abdel Mageed AM;Isobe N and Yoshimura Y
• 通讯作者: Isobe N and Yoshimura Y

Effects of lipopolysaccharide on the expression of proinflammatory cytokines and chemokines and the subsequent recruitment of immunocompetent cells in the oviduct of laying and molting hens

• DOI: 10.3382/ps.2011-01596
• 发表时间: 2011-10-01
• 期刊: POULTRY SCIENCE
• 影响因子: 4.4
• 作者: Nii, T.;Sonoda, Y.;Yoshimura, Y.
• 通讯作者: Yoshimura, Y.

Effects of repeated stimulation by lipopolysaccharide on the antigen presenting cell-T cell associated immunity in hen vagina.

脂多糖重复刺激对母鸡阴道抗原呈递细胞-T细胞相关免疫的影响。

• 发表时间: 2012
• 作者: Takahiro Nii;Naoki Isobe;and Yukinori Yoshimura
• 通讯作者: and Yukinori Yoshimura

Expressions of tight junction molecule "claudins" in the lower oviductal segments and their changes with gonadal steroids stimulation in the laying and molting hens

蛋鸡和换羽母鸡输卵管下段紧密连接分子“claudins”的表达及其性腺类固醇刺激的变化

• 发表时间: 2012
• 作者: Bambang Ariyadi;Naoki Isobe;Yukinori Yoshimura
• 通讯作者: Yukinori Yoshimura

Effects of Repeated Lipopolysaccharide Stimulation on the Development of Antigen-presenting Cells and T Cells Pool in Hen Vagina

• DOI: 10.2141/jpsa.0120086
• 发表时间: 2013-01-01
• 期刊: JOURNAL OF POULTRY SCIENCE
• 影响因子: 1.5
• 作者: Nii, Takahiro;Isobe, Naoki;Yoshimura, Yukinori
• 通讯作者: Yoshimura, Yukinori