C-11 acetate PET for the diagnosis of malignancy

C-11 醋酸盐 PET 诊断恶性肿瘤

• 批准号: 10670841
• 负责人: TAKAHASHI Norio
• 金额: $ 1.15万
• 依托单位: Fukui Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670841/
• 关键词: C-11 acetate; F-18 FDG; Positron emission tomography (PET); Prostate cancer; NO

We introduced carbon-11(C-11) acetate PET for positive imaging of prostate cancer (PC) and evaluated the usefulness of C-11 acetate PET in comparison with FDG PET. Seventeen patients with PC underwent both C-11 acetate and F-18 FDG PET and one patient with benign prostate hyperplasia (BPH) underwent only C-11 acetate PET. C-11 acetate PET images of BPH showed faint uptake in the prostate and radioactivity in the urinary bladder was negligible. C-11 acetate PET visualized primary PC and its metastases in the pelvic region and sensitivity of primary lesions of C-11 acetate PET was superior to that of F-18 FDG PET. C-11 acetate uptake in the PC reflected clinical therapy response. From basic study using tumor cell lines, fibroblast, C-14 acetate and H-3 thymidine, it was found that C-14 accumulation in tumor cells was due to the anabolic pathway of acetate, and refrected the growth activity. Accordingly, C-11 acetate might be appropriate for estimating the growth activity of tumor cells. C-11 acetate PET is expected to be a simple and useful method for positive imaging of the primary PC and its metastases.

我们介绍了碳-11（C-11）乙酸PET的前列腺癌（PC）的积极成像，并评估了C-11乙酸PET与FDG PET相比的有用性。17例PC患者同时接受了C-11醋酸盐和F-18 FDG PET，1例良性前列腺增生（BPH）患者仅接受了C-11醋酸盐PET。BPH的C-11醋酸盐PET图像显示前列腺中的微弱摄取，膀胱中的放射性可忽略不计。C-11醋酸盐PET对原发性前列腺癌及其盆腔转移灶的显示能力优于F-18 FDG PET，且C-11醋酸盐PET对原发灶的敏感性上级。PC中的C-11醋酸盐摄取反映了临床治疗反应。从肿瘤细胞系、成纤维细胞、C-14乙酸和H-3胸苷的基础研究发现，C-14在肿瘤细胞中的积累是由于乙酸的合成代谢途径，并反映了生长活性。因此，C-11乙酸酯可能适用于估计肿瘤细胞的生长活性。C-11乙酸PET有望成为原发性PC及其转移瘤的一种简单而有用的阳性成像方法。

项目成果

S. Muramoto: "Positive imaging of prostate cancer with carbon-11 acetate and PET"The Journal of Nuclear Medicine. 40(Supple.). 60 (1999)

S. Muramoto：“用碳 11 醋酸盐和 PET 对前列腺癌进行阳性成像”《核医学杂志》。

村本 聡: "C-11 acetate PETによる前立腺癌イメージング"日本医学放射線学会雑誌. 60(2). S280 (2000)

Satoshi Muramoto：“使用 C-11 醋酸盐 PET 进行前列腺癌成像”，日本医学放射学会杂志 60(2)。

S. Muramoto: "Positive imaging of prostate cancer with carbon-11 acetate and PET."The Journal of Nuclear Medicine. 40(Suppl.). 60 (1999)

S. Muramoto：“用碳 11 醋酸盐和 PET 对前列腺癌进行阳性成像。”《核医学杂志》。

S. Muramoto: "Imaging of prostate cancer with C-11 acetate PET."Nippon Acta Radiologica. 60(2). S280 (2000)

S. Muramoto：“使用 C-11 醋酸盐 PET 对前列腺癌进行成像。”Nippon Acta Radiologica。

S. Muramoto: "Positive imaging of prostate cancer with carbon-11 acetate and PET."The Journal of Nuclear Medicine. 40(Supple.). 60P (1999)

S. Muramoto：“用碳 11 醋酸盐和 PET 对前列腺癌进行阳性成像。”《核医学杂志》。