Basic evaluation of a single probe system for lymph node detection with F-18 FDG

F-18 FDG 淋巴结检测单探针系统的基本评估

• 批准号: 13670967
• 负责人: SUZUKI Yutaka
• 金额: $ 2.24万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670967/
• 关键词: Single-probe system; Sentinel lymph node; F-18 FDG; Radio-guided surgery; 測定器性能評価ファントーム; ラディオガイド下手術; プローブ型検出器; 等反応曲線; シングルプローブ

The gamma probe system developed consists of a NaI(T1) detector 9mm in diameter, a data acquisition unit ,central processing unit and data display unit. Two different kinds of tungsten collimators were constructed for Tc-99m: One is a straight bore of 40mm in length, 9mm in diameter and 3.5mm in wall thickness. The distance between the tip of the collimator and the detector is variable from 0 to 20mm. The other is a one with tapered tip, the diameter decreasing from 8mm to 3mm within 5mm distance. The distance between the tip of the collimator and the surface of the detector is variable from 5mm to 20mm. Two different types of tungsten collimator for F-18 were constructed: One is a straight bore type of 9mm in diameter, 33mm in length and 10mm in thickness. The other is one with tapering tip; 3mm in the tip diameter, 9mm in diameter at the 5mm from the tip, 23mm in length and 10mm in thickness. The counting rate performance of the system was studied with Tc-99m and F-18. The response curve of each collimator in water was obtained. Minimum differentiation of two point sources was determined in each collimator. The side penetration of 511keV photon was checked in the detector system for F-18.There was linear relationship between activities and counts up to 35kcps for both nuclides. The sensitivity in water was rapidly decreased with the straight bore collimator: 70% at the depth of 20mm. With the tapering collimator the sensitivity loss in water was gradual: 80% at 40mm. The minimum differentiation capability was 20mm with the tapering collimator and 180mm with straight bore collimator. The side penetration of 511keV photon was less than 10%.These results indicate that this system may be a useful aid for sentinel node detection or lymph node metastasis detection with F-18 FDG.

开发的伽马探针系统由直径9mm的NAI（T1）检测器组成，数据采集单元，中央处理单元和数据显示单元。为TC-99M构建了两种不同类型的钨准直仪：一个是长度为40mm的直孔，直径9mm，壁厚3.5mm。准直仪和检测器的尖端之间的距离从0到20mm。另一个是一个带有锥形尖端的，直径在5mm范围内从8mm降低到3mm。准直仪和检测器表面之间的距离从5mm到20mm。构建了两种不同类型的F-18钨准直仪：一种是直径为9mm的直孔类型，长度为33mm，厚度为10mm。另一个是一个带有锥形尖端的；尖端直径为3mm，直径为9mm，距尖端5mm，长23mm，厚度为10mm。使用TC-99M和F-18研究了系统的计数性能。获得了水中每个准仪的响应曲线。在每个准仪中确定了两个点源的最小分化。在探测器系统中检查了511KeV光子的侧面穿透是否有F-18。两个核素的活性与高达35kcps之间的线性关系。随着直孔直接仪的速度，水的灵敏度迅速降低：深度为20mm的70％。使用锥形准直仪，水的灵敏度损失逐渐：40mm时80％。锥度准直晶石器的最小分化能力为20mm，而直孔直接仪为180mm。 511KeV光子的侧面穿透率小于10％。这些结果表明，该系统可能是前哨淋巴结检测或使用F-18 FDG检测的有用帮助。

项目成果

K. Ban: "Estimation of left ventricular systolic pressure by the left ventricular volume-time curve obtained from electrocardiograph gated Tc-99m"Nuclear Medicine Communications. 23-(1). 175-179 (2002)

K. Ban：“通过心电图门控 Tc-99m 获得的左心室容积-时间曲线估算左心室收缩压”《核医学通讯》。

Takatoshi Kakuta: "Prognosis of parathyroid function after minimally invasive radio-guided parathyroidectomy(MIRP) and percutaneous ethanol injection(PEIT)"Biomed Pharmacother. 56(Special). 41S-47S (2002)

Takatoshi Kakuta：“微创无线电引导甲状旁腺切除术（MIRP）和经皮乙醇注射（PEIT）后甲状旁腺功能的预后”Biomed Pharmacother。

Seiei Yasuda: "Preliminary study for sentinel lymph node identification with Tc-99m tin colloid in patients with esophageal or gastric cancer"Tokai J Exp Clin Med. 26. 15-18 (2001)

Seiei Yasuda：“食管癌或胃癌患者中 Tc-99m 锡胶体识别前哨淋巴结的初步研究”Tokai J Exp Clin Med。

Takatoshi Kakuta: "Prognosis of parathyroid function after minimally invasive radio-guided parathyroidectomy and percutaneous ethanol injection therapy"Biomed Pharmacother. 56. 41s-47s (2002)

Takatoshi Kakuta：“微创无线电引导甲状旁腺切除术和经皮乙醇注射治疗后甲状旁腺功能的预后”Biomed Pharmacother。

M. Ohta: "Whole body PET for the evaluation of bony metastas in patients with breast cancer: comparison with Tc-99m MDP bone scintigraphy"Nuclear Medicine Communications. 22-(6). 875-879 (2001)

M. Ohta：“用于评估乳腺癌患者骨转移的全身 PET：与 Tc-99m MDP 骨闪烁扫描的比较”《核医学通讯》。