Role of the P73 gene in the blast crisis of chronic myelocytic leukemia

P73基因在慢性粒细胞白血病急变中的作用

• 批准号: 10670972
• 负责人: MORI Naoki
• 金额: $ 1.09万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670972/
• 关键词: CML; TUMOR SUPRESSOR GENE

Cytogenetic analysis showed no deletions of chromosome arm 1p in 70 patients with chronic myelocytic luekemia. Deletional mapping of 1p revealed that common region of loss of heterozygosity is proximal to D1S508 and distal to D1S507. RT-PCR analysis of the p73 gene was performed in 35 samples of CML. Expression of the gene was detected in most of the samples and gel electrophoresis showed no apparent abnormality of the cDNA products.

70例慢性粒细胞白血病患者的细胞遗传学分析均未发现染色体臂1 p缺失。1 p的缺失定位显示，共同的杂合性缺失区域是D1 S508的近端和D1 S507的远端。对35例CML患者的p73基因进行了RT-PCR分析。在大多数样品中检测到该基因的表达，凝胶电泳显示cDNA产物无明显异常。

项目成果

Mori N: "Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia."Blood. 92. 3405-3409 (1998)

Mori N：“染色体带 1p36 包含一个假定的肿瘤抑制基因，在慢性粒细胞白血病的进化中很重要。”血液。

Mori N: "Allelic loss in the progression of myelodysplastic syndrome"Cancer Research. (in press).

Mori N：“骨髓增生异常综合征进展中的等位基因丢失”癌症研究。

Mori N: "Chromosome band 1p36 contains putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia."Blood. 92. 3405 (1998)

Mori N：“染色体带 1p36 包含假定的肿瘤抑制基因，在慢性粒细胞白血病的进化中很重要。”血液。

Mori N: "Allelic loss in the progression of mylodysplastic syndrome."Cancer Research. (in press).

Mori N：“骨髓增生异常综合征进展中的等位基因丢失。”癌症研究。

Mori N: "Allelic loss in the progression of myelodysplastic syndrome."Cancer Research. (in press).

Mori N：“骨髓增生异常综合征进展中的等位基因丢失。”癌症研究。