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Experimental study for detecting cervical lymph node micro-metastasis using Doppler ultrasonography

多普勒超声检测颈部淋巴结微转移的实验研究

基本信息

批准号：
10671770
负责人：
YUASA Kenji
金额：
$ 1.66万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671770/
关键词：
Oral cancer Micro-metastasis Cervical lymph node metastasis Power Doppler ultrasonography Pulse Doppler ultrasonography VX2 cancer 頚部転移リンパ節超音波ドプラ法

项目摘要

Results of this study were as follows :1. Power Doppler ultrasonography (US) of cervical metastatic lymph nodes in rabbit with oral carcinoma (VX2 carcinoma implanted) using high frequency transducers (14MHz) was compared with intranodal angiography. Power Doppler Us could present intranodal vascularization almost compatible to intranodal angiography. Therefore, it was considered that power Doppler Us was useful to assess the intranodal angioarchitecture.2. Histopathologic finding and angiography showed that intranodal vasculization increased transiently in early stage of the tumor growth in lymph node, and thereafter decreased as the tumor growth advanced. In some case, peripheral vascularization of metastatic lymph node was found in advanced stage of intranodal tumor growth. Power Doppler Us could also reveal these change of intranodal vascularization in the tumor growth process.3. Pulse Doppler Us showed that velocity of blood flow at hilar region increased transiently in early stage of the tumor growth in lymph node, thereafter decreased as the tumor growth advanced. The phase of the maximum velocity of blood flow at hilar region associated with the phase then focal area of no perfusion was shown.4. Pulse Doppler Us showed that the vessel at hilar region had beats as the velocity of the blood flow increased.5. Peripheral blood flow was found in some cases of the metastatic lymph nodes when area of no perfusion within lymph node was presented.6. Above results suggested that when tumor implants in lymph node, firstly the velocity blood flow at hilar increase, and then intranodal vascularization increase transiently, and thereafter intranodal vascularization decrease as the tumor growth advanced, accompanying with the presence of peripheral vascularization in some cases.7. It was considered that we could detect cervical lymph node metastasis in early stage (micro-metastasis) using Doppler US.

本研究结果如下：1。采用14MHz高频超声对兔口腔癌（VX2癌植入）颈部转移淋巴结的功率多普勒超声（US）与结内血管造影进行比较。功率多普勒超声显示结内血管化与结内血管造影几乎一致。因此，我们认为功率多普勒超声可用于评估结内血管结构。组织病理学和血管造影显示淋巴结肿瘤生长早期结内血管化短暂增加，随后随着肿瘤生长的进展而减少。在结内肿瘤生长的晚期，一些病例发现转移性淋巴结周围血管化。功率多普勒超声还能显示肿瘤生长过程中结内血管化的变化。脉搏多普勒示淋巴结肿瘤生长早期肺门区血流速度短暂升高，随着肿瘤生长的进展血流速度逐渐降低。显示肝门区最大血流速度与无灌注灶区相对应的相位。脉搏多普勒显示，随着血流速度的增加，门区血管有搏动。5 .部分转移性淋巴结内无灌注区，可见外周血流。以上结果提示，当肿瘤植入淋巴结时，首先在淋巴结门处血流速度增加，然后在结内血管形成短暂性增加，随后随着肿瘤生长的进展，结内血管形成逐渐减少，部分病例伴有外周血管形成。认为多普勒超声可以早期发现颈部淋巴结转移（微转移）。