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Eye movement control signals carried by cerebellar nucleus neuron population

小脑核神经元群携带的眼动控制信号

基本信息

批准号：
10680759
负责人：
IWAMOTO Yoshiki
金额：
$ 2.05万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680759/
关键词：
cerebellum eye movement monkey muscimol サッケード

项目摘要

The caudal part of the fastigial nucleus, or fastigial oculomotor region (FOR), has been implicated in producing saccades of the correct size. Based on the results of previous studies, it has been hypothesized that burst activity of saccade-related FOR neurons ensures saccade accuracy by reducing the motoneuron burst for ipsiversive saccades that would otherwise overshoot a target (Fuchs et al. 1993 ; Ohtsuka and Noda 1995 ; Robinson 1993). One prediction of the hypothesis is that the horizontal end position error of ipsiversive saccades following FOR inactivation should reflect the burst activity that the FOR cells would normally exhibit. The present study tests this prediction using rhesus monkeys (Macaca mulatta). In agreement with previous reports, unilateral FOR injection resulted in hypermetria of ipsi-, and hypometria of contraversive saccades. Vertical saccades were mildly hypermetric and deviated toward the injection side. For ipsiversive movements, there was a linear relationship between horizontal end position error (overshoot) and horizontal initial retinal error (RE). For vertical saccades, horizontal end position error (deviation) was linearly correlated with vertical initial RE. For unit activity was then analyzed. The number of spikes in the burst (NumSp) for ipsiversive saccades was correlated with horizontal initial RE. For vertical saccades, there was a linear relationship between NumSp and vertical initial RE. The similar dependency of horizontal end position error and fastigial burst activity on RE supports the idea that FOR cells exhibit correction signals that maintain saccade accuracy.

小脑顶核的尾侧部分，或小脑顶眼区（FOR），已经被牵涉到产生正确大小的扫视。基于先前研究的结果，已经假设扫视相关的FOR神经元的爆发活动通过减少可能超过目标的同向扫视的运动神经元爆发来确保扫视准确性（Fuchs等人，1993 ; Ohtsuka和Noda 1995 ;罗宾逊1993）。该假设的一个预测是，FOR失活后的同向扫视的水平末端位置误差应该反映FOR细胞通常表现出的爆发活动。本研究使用恒河猴（Macaca mulatta）测试这一预测。与以前的报道一致，单侧FOR注射导致同侧眼跳的远视和逆向眼跳的远视。垂直扫视轻度高，偏向注射侧。对于同向运动，水平末端位置误差（过冲）和水平初始视网膜误差（RE）之间存在线性关系。对于垂直扫视，水平末端位置误差（偏差）与垂直初始RE呈线性相关。然后对单位活性进行分析。同向扫视的爆发中的棘波数（NumSp）与水平初始RE相关。对于垂直扫视，NumSp与垂直初始RE之间存在线性关系。水平末端位置误差和顶突发活动对RE的类似依赖性支持FOR细胞表现出维持扫视准确性的校正信号的想法。