权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

cerebellar output pathway involved in saccadic gain adaptation

小脑输出通路参与扫视增益适应

基本信息

批准号：
13680894
负责人：
IWAMOTO Yoshiki
金额：
$ 1.66万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680894/
关键词：
Saccada adaptation motor learning monkey cerebellum fastigiel nucleus 可塑性

项目摘要

1) Effects of inactivating the fastigial oculomotor region (FOR) in the monkey Unilateral inactivation of the FOR is known to result in marked hypermetria of ipsiversive saccades. It remains an open question whether this is due to a uniform gain change over saccades of different amplitudes, i.e., a parametric gain change, or due, instead, to an overshoot of a constant size regardless of movement amplitudes, as suggested by a previous study in the cat. We analyzed dysmetria following unilateral FOR inactivation in the monkey and concluded that the resultant overshoots were due to a uniform gain increase for saccades of all sizes.2) Changes in FOR activity during saccadic adaptation The results of the above and other FOR inactivation studies suggest that the FOR exerts a suppressive action on ipsiversive saccades. If the FOR is involved in adaptive modification of saccade amplitude, its saccade-related activity is expected to increase as the saccade size in decreased. We recorded from single FOR neurons in the monkey as the gain of ipsiversive saccades was decreased. The FOR activity was found to increase as the gain was decreased. During the course of adaptation, the neuronal activity and gain were altered with a similar course but in the opposite directions. The results are thus consistent with the hypothesized suppressive action of FOR activity on ipsiversive saccades and provide support on a single neuron basis for the cerebellar involvement in saccadic adaptation.

1) 猴子顶动眼运动区 (FOR) 失活的影响已知 FOR 的单侧失活会导致同向眼跳的显着远视。这是否是由于不同幅度的扫视的均匀增益变化（即参数增益变化）引起的，还是由于无论运动幅度如何而恒定大小的过冲（如之前对猫的研究所表明的那样）仍然是一个悬而未决的问题。我们分析了猴子单侧 FOR 失活后的辨距障碍，得出的结论是，所产生的超调是由于所有尺寸的扫视增益均匀增加所致。 2）扫视适应过程中 FOR 活性的变化上述和其他 FOR 失活研究的结果表明，FOR 对同向扫视发挥抑制作用。如果 FOR 参与扫视幅度的适应性修改，则其与扫视相关的活动预计会随着扫视大小的减小而增加。我们从猴子的单个 FOR 神经元中记录了随着同向扫视增益减少的情况。发现随着增益的减少，FOR 活性增加。在适应过程中，神经元活动和增益以类似的过程但方向相反的方式发生改变。因此，结果与假设的 FOR 活动对运动性扫视的抑制作用一致，并在单神经元基础上为小脑参与扫视适应提供了支持。