Biosignal responsive drug delivery system by using bioactive polymer/ceramic composite bone cement

采用生物活性聚合物/陶瓷复合骨水泥的生物信号响应药物递送系统

• 批准号: 10680809
• 负责人: OTSUKA Makoto
• 金额: $ 2.24万
• 依托单位: KOBE PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10680809/
• 关键词: Biomaterials; Bis-GMA; Drug delivery system; Cephalexin; Artificial bone; hydroxyapatite; bioaffinity; bone activity

Effect of formulation of the bioactive bone cements on cephalexin (CEX) release from cement consisting of synthesis or natural polymers and apatite related ceramics powder was investigated. Bisphenol-α-glycidyl methacrylate (Bis-GMA), triethylene-glycol dimethacrylate (TEGDMA) resin and apatite- and wollastonite-containing glass-ceramic (A-W GC) powder containing CEX powder hardened within 5 min after mixing with Bis-GMA/TEGDMA resin, and furthermore its compressive strength was expected to be higher than that of polymethylmethacrylate cement. In vitro CEX release from bioactive bone cement pellets in simulated body fluid at pH 7.25 and 37℃ continued for more than 2 weeks. The drug release rate increased with increasing amount of CEX in the mixture. All of the drug release profiles the Higuchi equation at the initial stage, but not at later stages. As hydroxyapatite was precipitated out on the cement surface, the drug release rate decreased. These results suggest that the CEX release rate from bioactive bone cement could be controlled by varying the amount of drug in the cement system.

研究了生物活性骨水泥的配方对合成或天然高分子与磷灰石相关陶瓷粉末组成的骨水泥中头孢氨苄（CEX）释放的影响。双酚-α-甲基丙烯酸缩水甘油酯（Bis-GMA）、三甘醇二甲基丙烯酸酯（TEGDMA）树脂和含有CEX粉末的含磷灰石和硅灰石的玻璃陶瓷（A-W GC）粉末在与Bis-GMA/TEGDMA树脂混合后在5 min内硬化，并且其压缩强度预期高于聚甲基丙烯酸甲酯水泥。在pH 7.25和37℃的模拟体液中，生物活性骨水泥颗粒的体外CEX释放持续超过2周。药物释放速率随着混合物中CEX量的增加而增加。所有的药物释放曲线在初始阶段符合Higuchi方程，但在后期不符合。随着羟基磷灰石在骨水泥表面析出，药物释放速率降低。这些结果表明，CEX从生物活性骨水泥中的释放速率可以通过改变骨水泥系统中药物的量来控制。

项目成果

M. Otsuka, K.Yoneoka, et al.: "Effect of Plasma-calcium-level-responsive Oestradiol Release From Apatitic Bone Cement on Bone Mineral Density in Ovariectomized Rats, and Its Physicochemical Mechanism"J. Pharm. Pharmacol.,. 51,. 475-481 (1999)

M. Otsuka，K.Yoneoka，等人：“磷灰石骨水泥中血浆钙水平响应性雌二醇释放对卵巢切除大鼠骨矿物质密度的影响及其理化机制”J。

伊藤允好ら: "平成10年度(第23回)学術研究振興資金学術研究報告"財団法人日本私学振興・共催事業団. 177-183 (1999)

Masaaki Ito 等：“1998 财年（第 23 期）学术研究促进基金学术研究报告”日本私立教育振兴基金会 177-183（1999）。

M. Otsuka et al.: "Effect of Geometrical Cement Size on in vitro and in vitro Indomethacin Release from Self-Setting Apatite Cement"J. Controlled Release.. 52(1). 281-289 (1998)

M. Otsuka 等人：“几何水泥尺寸对自凝磷灰石水泥中体外和体外吲哚美辛释放的影响”J。

A. Chhettry et al.: "Metastable Equilibrium Solibility Distribution of Carbonated Apatite as Function of Solution Composition"J. Colloid Int. Sci.. 218. 57-67 (1999)

A. Chhettry 等人：“碳酸磷灰石的亚稳态平衡溶解度分布作为溶液成分的函数”J。

M.Otsuka,M.Sawada,et al.: "Effect of Water-soluble Component Content on Cephalexin Release from Bioactive Bone Cement Consisting of bis-GMA/TEGDMA Resin and Bioactive Glass Ceramics."J.Mat.Sci.;Materials in Medicine,. 10. 59-64 (1999)

M.Otsuka，M.Sawada，等人：“水溶性成分含量对由双 GMA/TEGDMA 树脂和生物活性玻璃陶瓷组成的生物活性骨水泥中头孢氨苄释放的影响。”J.Mat.Sci.；Materials in