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Development and Application of the non-invasive high-resolutional structural analysis system for bone tissue

非侵入性高分辨率骨组织结构分析系统的开发与应用

基本信息

批准号：
11357016
负责人：
OZAWA Hidehiro
金额：
$ 22.98万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A).
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11357016/
关键词：
micro CT bone tissure bone density three dimensional structure cone beam type 被爆線量高分解能形態解析システム 3次元画像高速CT3次元再構成方式

项目摘要

The development of high-resolutional microfocus x-ray computed tomography(micro CT)was carried out in order to investigate the kind of changes occurring during the experimental stages of the study of the bone density of animal and three dimensional structure.[Relationships and considerations of image conditions regarding exposed radiation dose and image quality.]Through utilization of a cone beam type high-sensitivity detector and a shortened exposure time, we achieved a speeding-up of the reconstruction of a 3D image. At the time of exposed radiation dose was reduced by 1/16-1/50 compared with other methods used to date, however the desired target of 110 micro SV resulted in 12-35 times the radiation dosage. In order to reduce the exposed radiation dose even further, the high-sensitivity detector was re-examined and trials were carried o utilizing a 2048 x 2048 pixel 12 bit digital flat panel detector.[Development of a rigid table upon which animals can be stabilized for use with x-ra … More y computed tomography equipment.]We successfully completed a preliminary design of micro CT equipment for use with dogs, monkeys, rabbits and other larger animals.[Establishment of a bone volume density measurement and evaluation system.]Regarding several combinations of cortical bone with the same volume density phantom and trabecular bone with the same volume density phantom, it became possible to achieve a method by which the CT value quantitative effect received for both cortical bone and trabecular bone was the same. In this way the absolute density of the trabecular bone can be precisely obtained.[Applications of the newly developed high-resolutional micro CT.]Changes in monkey mandible achieved through ovaliextomy and the changes in a mouse which had been administered with doses of vitamin D and skeletal abnormality of the Gli-gene knock out mouse could be clearly observed. These findings were reported at both the Annual Meeting of the Japanese Society for Bone and Minearl Research and the Annual Meeting of the American Society for Bone and Mineral Research. Less

为了研究在动物骨密度和三维结构研究的实验阶段发生的变化，进行了高分辨率微焦点X射线计算机断层扫描（microCT）的开发。[关于暴露辐射剂量和图像质量的图像条件的关系和考虑。]通过使用锥形束型高灵敏度探测器和缩短曝光时间，我们实现了3D图像重建的加速。与迄今为止使用的其他方法相比，暴露时的辐射剂量减少了1/16-1/50，然而，110微SV的期望目标导致辐射剂量的12-35倍。为了进一步降低暴露的辐射剂量，重新检查了高灵敏度探测器，并使用2048 x 2048像素12位数字平板探测器进行了试验。[开发一种刚性台，动物可以稳定在其上，以用于X射线照相 ...更多信息 y计算机断层扫描设备。]我们成功地完成了微型CT设备的初步设计，用于狗，猴子，兔子和其他较大的动物。[骨体积密度测量和评价系统的建立。]关于具有相同体积密度体模的皮质骨和具有相同体积密度体模的松质骨的几种组合，可以实现皮质骨和松质骨两者所获得的CT值定量效果相同的方法。通过这种方式，可以精确地获得骨小梁的绝对密度。【新开发的高分辨率微型CT的应用】可以清楚地观察到通过卵切除术获得的猴下颌骨的变化和给予一定剂量维生素D的小鼠的变化以及Gli基因敲除小鼠的骨骼异常。这些发现在日本骨与矿物质研究学会年会和美国骨与矿物质研究学会年会上都有报道。少