The effects of tinnitus inducing drugs on auditory cortex and cochlear nerve.

耳鸣诱导药物对听觉皮层和耳蜗神经的影响。

• 批准号: 11671711
• 负责人: OCHI Kentaro
• 金额: $ 0.51万
• 依托单位: St.Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671711/
• 关键词: tinnitus; primary auditory cortex; secondary auditory cortex; cochlear nerve; salicylate; quinine; spontaneous activity; single unit; 聴皮質

There are several reports about the effects of tinnitus inducing drugs on auditory cortex or cochlear nerve. However, the relationship between the effects of tinnitus inducing drugs on the auditory cortex and those on the cochlear nerve remains unknown. The purpose of this study was to examine the effects of the tinnitus inducing drugs on auditory cortex and cochlear nerve simultaneously.Firstly, we confirmed the consistency of our recording up to over 7 hours. Secondary, we evaluated the effects of tinnitus inducing drugs : salicylate and quinine. Intra-venous administration of salicylate induced transient increase of spontaneous activity in the secondary auditory cortex while decrease or no change in the primary auditory cortex.The effects of salicylate on the spontaneous activity in the cochlear nerve remain obscure.The effects of intra-muscular quinine administration induced almost the same changes in spontaneous activity at three different recording sites.The effects of tinnitus inducing drugs were not same even in auditory pathway. The increase in spontaneous activity in the secondary auditory cortex may be related to the production of tinnitus. It was obscure how the changes in spontaneous activity observed in primary auditory cortex and cochlear nerve related to production of tinnitus.

关于耳鸣药物对听皮层或耳蜗神经的影响，已有多篇报道。然而，耳鸣诱导药物对听觉皮层和耳蜗神经的影响之间的关系仍然未知。本研究的目的是同时观察耳鸣药物对听觉皮层和耳蜗神经的影响。其次，我们评估了耳鸣诱导药物水杨酸盐和奎宁的效果。静脉注射水杨酸可引起次级听皮层自发活动的短暂增加，而初级听皮层的自发活动减少或无变化。肌肉注射奎宁引起的三个不同记录部位的自发活动变化几乎相同，而耳鸣诱导药物的作用则不同甚至在听觉通路中。在次级听觉皮层的自发活动的增加可能与耳鸣的产生。初级听皮层和耳蜗神经的自发活动变化与耳鸣的发生有何关系尚不清楚。

项目成果

Ochi K, Ohashi T, Kinoshita H, Kenmochi M, Kikuchi H, Nishino H, Kato I: "Effects of salicylate and quinine on CAP adaptation process."In : Hazell J (ed), Proc.of the Sixth International Tinnitus Seminar, Biddles Short Run Books Ltd., King's Lynn, Norfolk

Ochi K、Ohashi T、Kinoshita H、Kenmochi M、Kikuchi H、Nishino H、Kato I：“水杨酸盐和奎宁对 CAP 适应过程的影响”。见：Hazell J（编辑），第六届国际耳鸣研讨会的 Proc.，

西野裕仁,越智健太郎 他: "難聴・耳鳴・眩暈患者の内耳道MRI所見の分析"耳鼻臨. 92. 1191-1194 (1999)

Hirohito Nishino、Kentaro Ochi 等：“听力损失、耳鸣和眩晕患者的内耳道 MRI 结果分析”Otorhinoplasty 92. 1191-1194 (1999)。

Ohashi T, Ochi K, et al.: "The cochlear function of guinea pigs with experimental chronic renal failure: Electrocochleography, effect of noise exposure."Ann Otol Rhinol Laryngol. 108. 955-962 (1999)

Ohashi T、Ochi K 等人：“实验性慢性肾衰竭豚鼠的耳蜗功能：耳蜗电图、噪声暴露的影响。”Ann Otol Rhinol Laryngol。

Kinoshita H,Ochi K, et al.: "Serum zinc level in patients with tinnitus. In Proc.of the 6th International Tinnitus Seminar 1999"Biddles Short Run Books Ltd., King's Lynn, Norfolk. 531-533 (1999)

Kinoshita H、Ochi K 等人：“耳鸣患者的血清锌水平。1999 年第六届国际耳鸣研讨会的 Proc.”Biddles Short Run Books Ltd.，Kings Lynn，诺福克。

Ochi K, Ohashi T, et al.,: "Effects of salicylate and quinine on CAP adaptation process. In: Proc. of the Sixth International Tinnitus Seminar 1999."Biddles Short Run Books Ltd., King's Lynn, Norfolk. 183-188 (1999)

Ochi K、Ohashi T 等人：“水杨酸盐和奎宁对 CAP 适应过程的影响。见：1999 年第六届国际耳鸣研讨会论文集。”Biddles Short Run Books Ltd.，Kings Lynn，诺福克。