The effects of tinnitus inducing drugs on auditory cortex and cochlear nerve.

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There are several reports about the effects of tinnitus inducing drugs on auditory cortex or cochlear nerve. However, the relationship between the effects of tinnitus inducing drugs on the auditory cortex and those on the cochlear nerve remains unknown. The purpose of this study was to examine the effects of the tinnitus inducing drugs on auditory cortex and cochlear nerve simultaneously.Firstly, we confirmed the consistency of our recording up to over 7 hours. Secondary, we evaluated the effects of tinnitus inducing drugs : salicylate and quinine. Intra-venous administration of salicylate induced transient increase of spontaneous activity in the secondary auditory cortex while decrease or no change in the primary auditory cortex.The effects of salicylate on the spontaneous activity in the cochlear nerve remain obscure.The effects of intra-muscular quinine administration induced almost the same changes in spontaneous activity at three different recording sites.The effects of tinnitus inducing drugs were not same even in auditory pathway. The increase in spontaneous activity in the secondary auditory cortex may be related to the production of tinnitus. It was obscure how the changes in spontaneous activity observed in primary auditory cortex and cochlear nerve related to production of tinnitus.