Sensory processing downstream of primary auditory cortex

初级听觉皮层的感觉处理下游

• 批准号: 10843388
• 负责人: Justin Daniel Yao
• 金额: $ 10万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10843388
• 关键词: Acoustics; Address; Anatomy; Animal Model; Animals; Area; Attenuated; Auditory; Auditory Perception; Auditory area; Award; Behavioral; Bilateral; Chalk; Characteristics; Code; Cognitive deficits; Complex; Computer Models; Cues; Data; Decision Making; Detection; Discrimination; Environment; Genetic; Gerbils; Goals; Human; Impairment; In Vitro; Infusion procedures; Injections; Interneurons; Interview; Laboratories; Linear Models; Location; Measures; Mentors; Modality; Muscimol; Nervous System; Neurons; Neurosciences; New York; Non-linear Models; Occupations; Parietal Lobe; Pathway interactions; Pattern; Performance; Phase; Physiological; Physiology; Preparation; Process; Psychometrics; Psychophysics; Publications; Research; Rodent; Role; Saline; Science; Sensory; Signal Transduction; Site; Slice; Speech; Statistical Models; Stimulus; Surface; Task Performances; Techniques; Testing; Time; Training; Transfection; Universities; Viral; Viral Vector; Visual; Visual Cortex; attenuation; auditory pathway; auditory processing; awake; career; clinically relevant; design; designer receptors exclusively activated by designer drugs; developmental plasticity; excitatory neuron; experience; extracellular; hearing impairment; improved; innovation; light emission; multisensory; neural; neuromechanism; neurophysiology; nonhuman primate; novel; optogenetics; pharmacologic; programs; promoter; sensory input; sensory integration; skills; sound; visual information; wireless

Project Summary/Abstract Candidate: My career goal is to develop an independent research program that examines how hierarchical transformations of auditory information downstream of core auditory cortex supports sound-driven decisions. My previous training experiences has provided me with technical and intellectual skills on auditory neurophysiology, behavioral neuroscience, and hearing loss-induced deficits in auditory processing and perception. I propose to expand my skill set with additional training by conducting wireless cortical recordings while gerbils simultaneously perform a complex auditory task, pharmacological and chemogenetic attenuation of neural activity in awake- behaving animals, and statistical modeling of psychophysical and neural data. During the K99 phase, I will prepare my transition to independence by developing the necessary skills for producing a successful chalk talk, plan job interview strategies, and gain effective lab management applications. By the end of the R00 phase, I plan to have a strong publication record and ample preliminary data that will lead to a successful R01 application. Environment: The K99 phase of this will be award will take place in the Center for Neural Science at New York University; an ideal location for the proposed training phase of this award. My primary mentor, Dr. Dan Sanes, possesses 30+ years of experience in developmental plasticity and auditory neuroscience. His laboratory utilizes innovative physiological, pharmacological, and anatomical techniques that include in vitro slice physiology, wireless extracellular awake-behaving recordings, pharmacological manipulation of neural activity, optogenetics, and anatomical tract tracing with viral vectors. Additional mentoring will be provided by Dr. Xiaoqin Wang (John Hopkins University), who has 25+ years of experience as an expert in the neural coding of acoustic information along the auditory neuroaxis and neurophysiological recordings in awake preparations, and Dr. Roozbeh Kiani (New York University), who is an expert in the neural mechanisms of perceptual decision-making. Research: The neural representations of acoustic signals are transformed at each locus of an ascending auditory pathway. An example of a principal characteristic of this hierarchical processing is the increase of integration time (i.e., the time required to fully encode a sensory cue) across higher auditory cortices. Currently, it is less certain how auditory information is transformed downstream from core auditory cortex (ACx) where it becomes integrated with other sensory inputs, and supports sound-driven decisions. Perturbations of neural activity in parietal cortex (PC), a region downstream of ACx, will be made in animals performing an auditory temporal integration task to determine whether PC is necessary for the observed behavioral temporal integration times (K99). Wireless recordings will be made in ACx and PC from awake-behaving animals performing an auditory temporal integration task to reveal the neural representations that support perceptual integration times (K99). Similar approaches will be used to determine whether the neural representation of PC correlates and supports task performance during a combined multisensory condition (R00).

项目概要/摘要 候选人：我的职业目标是开发一个独立的研究项目，检查分层结构如何 核心听觉皮层下游听觉信息的转换支持声音驱动的决策。我的 以前的培训经历为我提供了听觉神经生理学的技术和智力技能， 行为神经科学，以及听力损失引起的听觉处理和感知缺陷。我建议 通过在沙鼠同时进行无线皮质录音的额外训练来扩展我的技能 执行复杂的听觉任务，清醒状态下神经活动的药理学和化学遗传学衰减 行为动物，以及心理物理和神经数据的统计模型。在K99阶段，我会 通过培养进行成功的粉笔演讲所需的技能，为我向独立的过渡做好准备， 规划工作面试策略，并获得有效的实验室管理应用程序。在 R00 阶段结束时，我 计划拥有良好的发表记录和充足的初步数据，以成功 R01 申请。 环境：本次颁奖的 K99 阶段将在纽约神经科学中心进行 大学;该奖项拟议培训阶段的理想地点。我的主要导师 Dan Sanes 博士， 在发育可塑性和听觉神经科学方面拥有30多年的经验。他的实验室利用 创新的生理学、药理学和解剖学技术，包括体外切片生理学、 无线细胞外清醒行为记录、神经活动的药理学操纵、光遗传学、 以及用病毒载体进行解剖道追踪。王晓勤博士（John 霍普金斯大学），作为声学信息神经编码专家拥有 25 年以上的经验 沿着听觉神经轴和清醒状态下的神经生理学记录，Roozbeh Kiani 博士 （纽约大学），感知决策神经机制专家。 研究：声音信号的神经表征在上行的每个基因座上进行转换 听觉通路。这种分层处理的主要特征的一个例子是增加 较高听觉皮层的整合时间（即完全编码感觉线索所需的时间）。现在， 目前还不太确定听觉信息如何从核心听觉皮层 (ACx) 向下游转化。 与其他感官输入集成，并支持声音驱动的决策。神经扰动 顶叶皮层 (PC)（ACx 下游区域）的活动将在执行听觉的动物中进行 时间整合任务，以确定 PC 是否对于观察到的行为时间整合是必要的 次（K99）。将在 ACx 和 PC 中对清醒行为的动物进行无线记录 听觉时间整合任务揭示支持知觉整合时间的神经表征 （K99）。类似的方法将用于确定 PC 的神经表征是否与 支持组合多感官条件下的任务表现 (R00)。