Sensory processing downstream of primary auditory cortex

初级听觉皮层的感觉处理下游

• 批准号: 10238772
• 负责人: Justin Daniel Yao
• 金额: $ 13.31万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10238772
• 关键词: Acoustics; Address; Anatomy; Animal Model; Animals; Area; Attenuated; Auditory; Auditory Perception; Auditory area; Award; Behavioral; Bilateral; Chalk; Characteristics; Code; Cognitive deficits; Complex; Computer Models; Cues; Data; Decision Making; Detection; Discrimination; Environment; Gerbils; Goals; Human; Impairment; In Vitro; Infusion procedures; Injections; Interneurons; Interview; Laboratories; Light; Linear Models; Location; Measures; Mentors; Modality; Muscimol; Nervous system structure; Neurons; Neurosciences; New York; Non-linear Models; Occupations; Parietal Lobe; Pathway interactions; Pattern; Performance; Pharmacology; Phase; Physiological; Physiology; Preparation; Process; Psychometrics; Psychophysics; Publications; Research; Rodent; Role; Saline; Science; Sensory; Signal Transduction; Site; Slice; Statistical Models; Stimulus; Surface; Task Performances; Techniques; Testing; Time; Training; Universities; Viral; Viral Vector; Visual; Visual Cortex; Wireless Technology; attenuation; auditory pathway; auditory processing; awake; base; career; clinically relevant; design; designer receptors exclusively activated by designer drugs; developmental plasticity; experience; extracellular; hearing impairment; improved; innovation; multisensory; neuromechanism; neurophysiology; nonhuman primate; novel; optogenetics; programs; promoter; relating to nervous system; sensory input; skills; sound; visual information

Project Summary/Abstract Candidate: My career goal is to develop an independent research program that examines how hierarchical transformations of auditory information downstream of core auditory cortex supports sound-driven decisions. My previous training experiences has provided me with technical and intellectual skills on auditory neurophysiology, behavioral neuroscience, and hearing loss-induced deficits in auditory processing and perception. I propose to expand my skill set with additional training by conducting wireless cortical recordings while gerbils simultaneously perform a complex auditory task, pharmacological and chemogenetic attenuation of neural activity in awake- behaving animals, and statistical modeling of psychophysical and neural data. During the K99 phase, I will prepare my transition to independence by developing the necessary skills for producing a successful chalk talk, plan job interview strategies, and gain effective lab management applications. By the end of the R00 phase, I plan to have a strong publication record and ample preliminary data that will lead to a successful R01 application. Environment: The K99 phase of this will be award will take place in the Center for Neural Science at New York University; an ideal location for the proposed training phase of this award. My primary mentor, Dr. Dan Sanes, possesses 30+ years of experience in developmental plasticity and auditory neuroscience. His laboratory utilizes innovative physiological, pharmacological, and anatomical techniques that include in vitro slice physiology, wireless extracellular awake-behaving recordings, pharmacological manipulation of neural activity, optogenetics, and anatomical tract tracing with viral vectors. Additional mentoring will be provided by Dr. Xiaoqin Wang (John Hopkins University), who has 25+ years of experience as an expert in the neural coding of acoustic information along the auditory neuroaxis and neurophysiological recordings in awake preparations, and Dr. Roozbeh Kiani (New York University), who is an expert in the neural mechanisms of perceptual decision-making. Research: The neural representations of acoustic signals are transformed at each locus of an ascending auditory pathway. An example of a principal characteristic of this hierarchical processing is the increase of integration time (i.e., the time required to fully encode a sensory cue) across higher auditory cortices. Currently, it is less certain how auditory information is transformed downstream from core auditory cortex (ACx) where it becomes integrated with other sensory inputs, and supports sound-driven decisions. Perturbations of neural activity in parietal cortex (PC), a region downstream of ACx, will be made in animals performing an auditory temporal integration task to determine whether PC is necessary for the observed behavioral temporal integration times (K99). Wireless recordings will be made in ACx and PC from awake-behaving animals performing an auditory temporal integration task to reveal the neural representations that support perceptual integration times (K99). Similar approaches will be used to determine whether the neural representation of PC correlates and supports task performance during a combined multisensory condition (R00).

项目摘要/摘要 候选人：我的职业目标是制定一个独立的研究计划，该计划探讨如何等级制度 核心听觉皮层下游的听觉信息的转换支持声音驱动的决策。我的 以前的培训经验为我提供了关于听觉神经生理学的技术和智力技能， 行为神经科学以及听力损失引起的听觉处理和感知缺陷。我建议 通过进行无线皮质记录，而Gerbils同时进行无线皮质记录，通过额外的培训来扩展我的技能 在清醒中执行复杂的听觉任务，药理和化学衰减 - 行为动物，以及心理物理和神经数据的统计建模。在K99阶段，我将 通过发展成功的粉笔谈话的必要技能来准备我向独立的过渡， 计划工作面试策略，并获得有效的实验室管理应用程序。到R00阶段结束时，我 计划具有强大的出版记录和足够的初步数据，这将导致成功的R01应用程序。 环境：K99阶段将是奖励，将在纽约神经科学中心举行 大学;该奖项拟议培训阶段的理想位置。我的主要导师Dan Sanes博士， 在发展可塑性和听觉神经科学方面拥有30多年的经验。他的实验室利用 包括体外切片生理的创新生理，药理和解剖技术， 无线细胞外醒目的记录，神经活动的药理学操纵，光遗传学， 和病毒载体的解剖学跟踪。王王博士将提供额外的指导（约翰 霍普金斯大学（Hopkins University）），在声学信息的神经编码方面拥有25年以上的专家经验 沿着听觉的神经障碍和神经生理记录在清醒的制剂中，Roozbeh Kiani博士 （纽约大学），他是感知决策的神经机制的专家。 研究：声信号的神经表示在上升的每个源 听觉路径。该等级处理的主要特征的一个例子是增加 在更高的听觉皮层上的集成时间（即完全编码感觉提示所需的时间）。现在， 不太确定如何将听觉信息从核心听觉皮层（ACX）下游转变 与其他感官输入集成在一起，并支持声音驱动的决策。神经的扰动 ACX下游区域的顶叶皮层（PC）的活性将在动物中进行听觉 时间整合任务，以确定PC是否对于观察到的行为时间整合需要 时代（K99）。无线记录将通过ACX和PC制作，由醒着的动物进行 听觉时间整合任务，以揭示支持感知整合时间的神经表示 （K99）。类似的方法将用于确定PC的神经表示是否相关，并且 在组合多感官条件（R00）期间支持任务性能。