Sensory processing downstream of primary auditory cortex

初级听觉皮层的感觉处理下游

• 批准号: 10238772
• 负责人: Justin Daniel Yao
• 金额: $ 13.31万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10238772
• 关键词: Acoustics; Address; Anatomy; Animal Model; Animals; Area; Attenuated; Auditory; Auditory Perception; Auditory area; Award; Behavioral; Bilateral; Chalk; Characteristics; Code; Cognitive deficits; Complex; Computer Models; Cues; Data; Decision Making; Detection; Discrimination; Environment; Gerbils; Goals; Human; Impairment; In Vitro; Infusion procedures; Injections; Interneurons; Interview; Laboratories; Light; Linear Models; Location; Measures; Mentors; Modality; Muscimol; Nervous system structure; Neurons; Neurosciences; New York; Non-linear Models; Occupations; Parietal Lobe; Pathway interactions; Pattern; Performance; Pharmacology; Phase; Physiological; Physiology; Preparation; Process; Psychometrics; Psychophysics; Publications; Research; Rodent; Role; Saline; Science; Sensory; Signal Transduction; Site; Slice; Statistical Models; Stimulus; Surface; Task Performances; Techniques; Testing; Time; Training; Universities; Viral; Viral Vector; Visual; Visual Cortex; Wireless Technology; attenuation; auditory pathway; auditory processing; awake; base; career; clinically relevant; design; designer receptors exclusively activated by designer drugs; developmental plasticity; experience; extracellular; hearing impairment; improved; innovation; multisensory; neuromechanism; neurophysiology; nonhuman primate; novel; optogenetics; programs; promoter; relating to nervous system; sensory input; skills; sound; visual information

Project Summary/Abstract Candidate: My career goal is to develop an independent research program that examines how hierarchical transformations of auditory information downstream of core auditory cortex supports sound-driven decisions. My previous training experiences has provided me with technical and intellectual skills on auditory neurophysiology, behavioral neuroscience, and hearing loss-induced deficits in auditory processing and perception. I propose to expand my skill set with additional training by conducting wireless cortical recordings while gerbils simultaneously perform a complex auditory task, pharmacological and chemogenetic attenuation of neural activity in awake- behaving animals, and statistical modeling of psychophysical and neural data. During the K99 phase, I will prepare my transition to independence by developing the necessary skills for producing a successful chalk talk, plan job interview strategies, and gain effective lab management applications. By the end of the R00 phase, I plan to have a strong publication record and ample preliminary data that will lead to a successful R01 application. Environment: The K99 phase of this will be award will take place in the Center for Neural Science at New York University; an ideal location for the proposed training phase of this award. My primary mentor, Dr. Dan Sanes, possesses 30+ years of experience in developmental plasticity and auditory neuroscience. His laboratory utilizes innovative physiological, pharmacological, and anatomical techniques that include in vitro slice physiology, wireless extracellular awake-behaving recordings, pharmacological manipulation of neural activity, optogenetics, and anatomical tract tracing with viral vectors. Additional mentoring will be provided by Dr. Xiaoqin Wang (John Hopkins University), who has 25+ years of experience as an expert in the neural coding of acoustic information along the auditory neuroaxis and neurophysiological recordings in awake preparations, and Dr. Roozbeh Kiani (New York University), who is an expert in the neural mechanisms of perceptual decision-making. Research: The neural representations of acoustic signals are transformed at each locus of an ascending auditory pathway. An example of a principal characteristic of this hierarchical processing is the increase of integration time (i.e., the time required to fully encode a sensory cue) across higher auditory cortices. Currently, it is less certain how auditory information is transformed downstream from core auditory cortex (ACx) where it becomes integrated with other sensory inputs, and supports sound-driven decisions. Perturbations of neural activity in parietal cortex (PC), a region downstream of ACx, will be made in animals performing an auditory temporal integration task to determine whether PC is necessary for the observed behavioral temporal integration times (K99). Wireless recordings will be made in ACx and PC from awake-behaving animals performing an auditory temporal integration task to reveal the neural representations that support perceptual integration times (K99). Similar approaches will be used to determine whether the neural representation of PC correlates and supports task performance during a combined multisensory condition (R00).

项目总结/摘要 候选人：我的职业目标是发展一个独立的研究项目，研究如何分层 核心听觉皮层下游的听觉信息的转换支持声音驱动的决策。我 以前的培训经验为我提供了听觉神经生理学方面的技术和知识技能， 行为神经科学和听力损失引起的听觉处理和感知缺陷。我建议 通过额外的训练来扩展我的技能， 执行复杂的听觉任务，清醒时神经活动的药理学和化学发生学衰减， 行为动物，以及心理物理和神经数据的统计建模。在K99阶段，我将 通过发展必要的技能来制作一个成功的粉笔谈话， 计划工作面试策略，并获得有效的实验室管理应用。在R 00阶段结束时，我 计划有一个强大的出版记录和充足的初步数据，将导致一个成功的R 01申请。 环境：K99阶段将在纽约的神经科学中心进行 大学;是该奖项拟议培训阶段的理想地点。我的主要导师丹·萨尼斯博士 在发育可塑性和听觉神经科学方面拥有30多年的经验。他的实验室利用 创新的生理学、药理学和解剖学技术，包括体外切片生理学， 无线细胞外唤醒行为记录，神经活动的药理学操纵，光遗传学， 以及用病毒载体追踪解剖结构。王晓琴博士（John 霍普金斯大学），他在声学信息的神经编码方面拥有25年以上的经验 沿着听觉神经轴和神经生理学记录在清醒的准备工作，和博士Roophih Kiani (New约克大学），他是知觉决策神经机制方面的专家。 研究：声学信号的神经表征在上行信号的每个位点都发生了变化。 听觉通路这种分层处理的主要特征的一个例子是 积分时间（即，完全编码感觉线索所需的时间）穿过更高的听觉皮层。目前， 听觉信息是如何从核心听觉皮层（ACx）向下游转化的， 与其他感官输入整合，并支持声音驱动的决策。神经元扰动 顶叶皮层（PC）的活动，ACx的下游区域，将在执行听觉刺激的动物中进行。 时间整合任务，以确定PC是否是所观察到的行为时间整合所必需的 倍（K99）。将在ACx和PC中对清醒动物进行无线记录， 听觉时间整合任务，以揭示支持知觉整合时间的神经表征 （K99）。类似的方法将被用来确定PC的神经表征是否相关， 支持多感官组合条件（R 00）期间的任务表现。