Functional Organization of Non-Primary Auditory Cortex

非初级听觉皮层的功能组织

• 批准号: RGPIN-2022-05068
• 负责人: Lomber, Stephen
• 金额: $ 5.68万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=763299
• 关键词: Functional; Organization; Non; Primary; Auditory

The goals of this NSERC-funded program are to understand higher-order auditory processing upon which functionally-based models of cerebral operations can be developed, and to train Highly Qualified Personnel (HQP) from diverse backgrounds in systems- and cognitive-level neurobiology. Background: Functional specialization is a characteristic of cerebral cortex organization. Regions of the cerebrum are specialized to perform particular sensory or motor functions. Within extrastriate visual cortex of humans, monkeys and cats, areas have been identified that are further specialized for spatial, motion, and pattern processing. The behavioural correlate for such functional specializations, or a "division of labour", within auditory cortex is largely unknown. The long-term goal of our research program is to elucidate the behavioral "division of labour" within cat auditory cortex and determine the relative contributions that the different auditory fields make to acoustically-mediated behaviors. These results, when combined with investigations of underlying neuronal activity and cerebral connections, will provide evidence for, or refute, which hierarchical or network theories best explain processing in auditory cortex. Proposed Work: In the proposed study, we combine a battery of behavioural tests, electrophysiological recording, and reversible deactivation to dissect the functional plan of auditory cortex. This project will examine the 13 regions of acoustically-responsive cortex: the four tonotopic fields (AI, AAF, PAF & VPAF) and nine non-tonotopic areas (AII, FAES, dPE, iPE, vPE, DZ, VAF, IN, & T). In the proposed experiments we will emphasize pattern and temporal processing in auditory cortex. We hypothesize that the use of the proposed tasks and stimuli will reveal, both behaviorally and electrophysiologically, that areas along the dorso-ventral plane have increasing stimulus specificity similar to that of the ventral "what" processing stream in extrastriate visual cortex. Significance: Overall, we plan to produce the first compendium of the multiple, yet unique, combinations of neural contributions each region of auditory cortex makes to the processing of pattern and temporal stimuli. The results from these studies are essential for the development of functionally-based models of cerebral operations that will form the foundation of future knowledge of emergent and higher-order integrative processes.

这个NSERC资助的计划的目标是了解高阶听觉处理，在此基础上可以开发基于功能的大脑操作模型，并培养来自系统和认知水平神经生物学不同背景的高素质人员（HQP）。背景：功能特化是大脑皮层组织的一个特征。大脑的某些区域专门负责执行特定的感觉或运动功能。在人类、猴子和猫的纹外视觉皮质内，已经发现了进一步专门用于空间、运动和模式处理的区域。听觉皮层内这种功能性专门化或“劳动分工”的行为相关性在很大程度上是未知的。我们的研究计划的长期目标是阐明猫听觉皮层内的行为“分工”，并确定不同的听觉场对听觉介导的行为的相对贡献。这些结果，当结合调查潜在的神经元活动和大脑连接，将提供证据，或反驳，层次或网络理论最好地解释在听觉皮层的处理。拟议工作：在这项研究中，我们结合联合收割机的电池的行为测试，电生理记录，和可逆性去激活解剖听觉皮层的功能计划。该项目将检查听觉反应皮层的13个区域：四个音调区域（AI，AAF，PAF和VPAF）和九个非音调区域（AII，FAES，dPE，iPE，vPE，DZ，VAF，IN和T）。在本实验中，我们将着重于听觉皮层的模式和时间处理。我们假设，所提出的任务和刺激的使用将揭示，无论是行为和电生理，该地区沿着背腹平面有增加刺激的特异性类似的腹侧“什么”在纹外视皮层的处理流。重要性：总的来说，我们计划制作第一个纲要的多个，但独特的，组合的神经贡献的每个区域的听觉皮层的处理模式和时间刺激。从这些研究的结果是必不可少的功能为基础的模型的大脑运作，将形成未来的知识的基础上出现和高阶整合过程的发展。