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Sensory processing downstream of primary auditory cortex

初级听觉皮层的感觉处理下游

基本信息

批准号：
10659074
负责人：
Justin Daniel Yao
金额：
$ 24.9万
依托单位：
RUTGERS BIOMEDICAL AND HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10659074
关键词：
Acoustics Address Anatomy Animal Model Animals Area Attenuated Auditory Auditory Perception Auditory area Award Behavioral Bilateral Chalk Characteristics Code Cognitive deficits Complex Computer Models Cues Data Decision Making Detection Discrimination Environment Gerbils Goals Human Impairment In Vitro Infusion procedures Injections Interneurons Interview Laboratories Light Linear Models Location Measures Mentors Modality Muscimol Nervous system structure Neurons Neurosciences New York Non-linear Models Occupations Parietal Lobe Pathway interactions Pattern Performance Pharmacology Phase Physiological Physiology Preparation Process Psychometrics Psychophysics Publications Research Rodent Role Saline Science Sensory Signal Transduction Site Slice Statistical Models Stimulus Surface Task Performances Techniques Testing Time Training Universities Viral Viral Vector Visual Visual Cortex attenuation auditory pathway auditory processing awake base career clinically relevant design designer receptors exclusively activated by designer drugs developmental plasticity experience extracellular hearing impairment improved innovation multisensory neuromechanism neurophysiology nonhuman primate novel optogenetics programs promoter relating to nervous system sensory input skills sound visual information wireless

项目摘要

Project Summary/Abstract Candidate: My career goal is to develop an independent research program that examines how hierarchical transformations of auditory information downstream of core auditory cortex supports sound-driven decisions. My previous training experiences has provided me with technical and intellectual skills on auditory neurophysiology, behavioral neuroscience, and hearing loss-induced deficits in auditory processing and perception. I propose to expand my skill set with additional training by conducting wireless cortical recordings while gerbils simultaneously perform a complex auditory task, pharmacological and chemogenetic attenuation of neural activity in awake- behaving animals, and statistical modeling of psychophysical and neural data. During the K99 phase, I will prepare my transition to independence by developing the necessary skills for producing a successful chalk talk, plan job interview strategies, and gain effective lab management applications. By the end of the R00 phase, I plan to have a strong publication record and ample preliminary data that will lead to a successful R01 application. Environment: The K99 phase of this will be award will take place in the Center for Neural Science at New York University; an ideal location for the proposed training phase of this award. My primary mentor, Dr. Dan Sanes, possesses 30+ years of experience in developmental plasticity and auditory neuroscience. His laboratory utilizes innovative physiological, pharmacological, and anatomical techniques that include in vitro slice physiology, wireless extracellular awake-behaving recordings, pharmacological manipulation of neural activity, optogenetics, and anatomical tract tracing with viral vectors. Additional mentoring will be provided by Dr. Xiaoqin Wang (John Hopkins University), who has 25+ years of experience as an expert in the neural coding of acoustic information along the auditory neuroaxis and neurophysiological recordings in awake preparations, and Dr. Roozbeh Kiani (New York University), who is an expert in the neural mechanisms of perceptual decision-making. Research: The neural representations of acoustic signals are transformed at each locus of an ascending auditory pathway. An example of a principal characteristic of this hierarchical processing is the increase of integration time (i.e., the time required to fully encode a sensory cue) across higher auditory cortices. Currently, it is less certain how auditory information is transformed downstream from core auditory cortex (ACx) where it becomes integrated with other sensory inputs, and supports sound-driven decisions. Perturbations of neural activity in parietal cortex (PC), a region downstream of ACx, will be made in animals performing an auditory temporal integration task to determine whether PC is necessary for the observed behavioral temporal integration times (K99). Wireless recordings will be made in ACx and PC from awake-behaving animals performing an auditory temporal integration task to reveal the neural representations that support perceptual integration times (K99). Similar approaches will be used to determine whether the neural representation of PC correlates and supports task performance during a combined multisensory condition (R00).

项目总结/文摘