课题基金 / 基金详情

Histologic and Electrophysiologic Study of Normal Neural Retinal Cell Transplantation in Mice with Retinal Degeneration

Histologic and Electrophysiologic Study of Normal Neural Retinal Cell Transplantation in Mice with Retinal Degeneration
视网膜变性小鼠正常神经视网膜细胞移植的组织学和电生理学研究
批准号：
11671761
负责人：
YAMAMOTO Shuichi
金额：
$2.11万
依托单位：
Toho University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
项目状态：
已结题
起止时间：
1999 至 2000
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671761/
关键词：
Retinal dystrophic miceNeural retinal cell transplantation網膜変性網膜移植網膜電図

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中文摘要
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英文摘要
1) The normal neural retinas obtained from transgenic mice have been successfully transplanted into the subretinal space of retinal dystrophic mice without immune suppression. Any sign of the immune rejection was not observed by the fundoscopic examination.2) It was found that the orientation of the differentiating photoreceptor outer segments were varied in each experiment and that the proper orientation could hardly archived in our current method.3) Several attempts to improve the results have been performed, and further histological and electrophysiological studies are needed.4) The TGF-beta neutralizing antibody successfully suppresses the development of experimental proliferative vitreoretinopathy in rabbit eyes.5) Electroretinograms were examined in patients with various retinal diseases to study retinal function, in order to compare with those in experimental animals.6) An LED built-in electrode was developed and tested in human eyes.
期刊论文(5)
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会议论文
Mitamura Y: "Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative vitreoretinopathy"American Journal of Ophthalmology. 128. 793-765 (1999)
Mitamura Y：“增殖性玻璃体视网膜病变患者玻璃体中巨噬细胞迁移抑制因子的水平”美国眼科杂志。
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通讯作者：
Mitamura Y: "Macrophage migration inhibitory factor level in the vitreous"American Journal of Ophthalmology. 129. 678-680 (2000)
Mitamura Y：“玻璃体内巨噬细胞迁移抑制因子水平”美国眼科杂志。
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Yamamoto,S.et al.: "Electroretinograms and visuall evoked potentials alicsted by spectral stimuli in a patient with enhauced S-cone syndrome"Jpn J Ophthalmol. 43. 433-437 (1999)
Yamamoto,S.et al.：“患有增强型 S 锥综合征的患者通过光谱刺激进行的视网膜电图和视觉诱发电位”Jpn J Ophamol。
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Yamamoto T: "Expression and possible role of Activin A in proliferative vitreoretinal diseases"Japanese Journal of Ophthalmology. 44. 221-226 (2000)
Yamamoto T：“激活素 A 在增殖性玻璃体视网膜疾病中的表达和可能的作用”日本眼科杂志。
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    24591554
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