Study of Blue Cone under Pathological Conditions in Rabbit Eyes

兔眼病理条件下蓝视锥细胞的研究

• 批准号: 17591821
• 负责人: YAMAMOTO Shuichi
• 金额: $ 2.18万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591821/
• 关键词: Electroretinogram; Blue cone; LED built-in contact lens electrode; Retinal degeneration; Rabbit eye

1) To examine the blue cone electroretinogram, we developed the blue LED built-in contact lens electrode.2) Responses from the blue cone were clearly and repeatedly recorded from normal human eyes using this new electrode.3) Temporal frequency characteristics obtained from the electroretinogram was quite similar those reported in previous psychophysical studies.4) Smaller contact lenses were developed for rabbit eyes, and the blue cone electroretinograms were successfully recorded.5) Electroretinograms were examined in patients with various retinal diseases, and in several animal models.

1)为了研究蓝锥视网膜电图，我们研制了一种蓝色LED内置接触透镜电极。2）使用这种新电极，从正常人眼中清楚地和重复地记录了蓝锥的反应。3）从视网膜电图获得的时间频率特性与以前的心理物理学研究中报道的非常相似。4）为兔眼研制了更小的接触透镜，5）对各种视网膜疾病患者和多种动物模型进行了视网膜电图检查。

项目成果

Pattern visual evoked potentials in eyes with disc swelling due to cat scratch disease-associated neuroretinitis.

因猫抓病相关神经视网膜炎而导致椎间盘肿胀的眼睛的图案视觉诱发电位。

• 发表时间: 2006
• 期刊: Doc Ophthalmol 50
• 作者: Chai Y;Yamamoto S;Hirayama A;Yotsukura J;Yamazaki H
• 通讯作者: Yamazaki H

Arpclb gene is a candidate prediction marker for choroidal malignant melanomas sensitive to radiotherapy

Arpclb基因是对放疗敏感的脉络膜恶性黑色素瘤的候选预测标记

• 发表时间: 2006
• 期刊: Invest Ophthalmol Vis Sci 47
• 作者: Aosai F;Rodriguez Pena MS;Mun H-S;Fang H;Mitsunaga T;Norose K;Kang HK;Bac Y-S;Yano A.;Kumagai K
• 通讯作者: Kumagai K

Deterioration of visual function as examined by electroretinograms in Toxoplasma gondii-infected IFN-gamma-knockout mice

通过视网膜电图检查弓形虫感染的 IFN-γ 敲除小鼠的视功能恶化

• 发表时间: 2005
• 期刊: Invest Ophthalmol Vis Sc 46
• 作者: Norose K;Aosai F;Mizota A;Yamamoto S;Mun HS;Yano A
• 通讯作者: Yano A

Deterioration of visual function as examined by electroretinograms in Toxoplasma gondii-infected IFN-gamma-knockout mice.

通过视网膜电图检查弓形虫感染的 IFN-γ 敲除小鼠的视功能恶化。

• 发表时间: 2005
• 期刊: Invest Ophthalmol Vis Sci. 46
• 作者: Norose K;Aosai F;Mizota A;Yamamoto S;Mun HS;Yano A
• 通讯作者: Yano A

Central retinal artery occlusion after radial optic neurotomy in a patient with central retinal vein occlusion

视网膜中央静脉阻塞患者放射状视神经切断术后视网膜中央动脉阻塞

• 发表时间: 2005
• 期刊: Am J Ophthalmol 139
• 作者: Norose K;Aosai F;Mizota A;Yamamoto S;Mun HS;Yano A;Oka M;Yamamoto S
• 通讯作者: Yamamoto S