Histopathologic and Electrophysiologic Study of Neonatal Normal Mouse Retina Transplanted into Retinal Dystrophic Mice

新生正常小鼠视网膜移植到视网膜营养不良小鼠体内的组织病理学和电生理学研究

• 批准号: 08672012
• 负责人: YAMAMOTO Shuichi
• 金额: $ 1.22万
• 依托单位: Toho University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672012/
• 关键词: Retinal Transplantation; Retinal Dystrophy; Transgenic Mouse; Electroretinogram; トランジェニックマウス

1) Transplanted neonatal mouse retina survived without immune suppression for a long period after the transplantation surgery.2) However, management of the photoreceptor polarity was very difficult, and in only a few cases, photoreceptor outer segments developed with proper direction.3) Several different methods of transplantation have been tried, however, any better surgical outcomes were not obtained, and further studies had to be postponed.4) Electroretinograms were examined in patients with different retinal diseases to study retinal function, in order to compare With that of dystrophic mice.

1)移植的新生小鼠视网膜在没有免疫抑制的情况下存活了很长一段时间。2)然而，光感受器的极性很难处理，只在少数情况下，光感受器外节沿着正确的方向发展。3)已经尝试了几种不同的移植方法，但没有获得更好的手术结果，进一步的研究还有待推迟。4)对不同视网膜疾病的患者进行视网膜电图检查，以研究视网膜功能，以便与营养不良小鼠的视网膜功能进行比较。

项目成果

Yamamoto S: "Cone electroretinogram to chromtic stimuli in myopic eyes" Vision Research. 37. 2157-2159 (1997)

Yamamoto S：“近视眼中色刺激的锥体视网膜电图”视觉研究。

Yamamoto S,Nitta K,Kamiyama M: "Cone electroretinogram to chromatic stimuli in myopic eyes." Vision Research. 37. 2157-2159 (1997)

Yamamoto S、Nitta K、Kamiyama M：“近视眼中彩色刺激的锥体视网膜电图。”

Yamamoto S,Hayashi M,Takeuchi S,Shirao Y,Kita K,Kawasaki K: "Normal S cone electroretinogram b-wave in Oguchi's disease." British Journal of Ophthalmology. 81. 1043-1045 (1997)

Yamamoto S、Hayashi M、Takeuchi S、Shirao Y、Kita K、Kawasaki K：“大口病中的正常 S 锥体视网膜电图 b 波。”

Yamamoto S: "Selective reduction of the S-cone electroretinogram in diabetes" British Journal of Ophthalmology. 80. 973-975 (1996)

Yamamoto S：“糖尿病中 S 锥体视网膜电图的选择性减少”英国眼科杂志。

Komiyama M: "Undetectable S-cone electroretinogram b-wave in congeutal stationary night blindness" British Journal of Ophthalnology. 80. 637-639 (1996)

Komiyama M：“先天性静止性夜盲症中无法检测到的 S 锥视网膜电图 b 波”英国眼科杂志。