Histological and electroghysiological study of neonatal mouse retina transplanted into RCS rat

将具有正常视网膜发育的正常新生小鼠或转基因新生小鼠的光感受器移植到正常大鼠的视网膜下间隙。移植动物在移植后的前两周接受水合物他克莫司（FK506）免疫抑制治疗或不接受治疗。移植后4周，只有他克莫司治疗的大鼠出现移植物存活。在12只接受治疗的眼睛中，有7只在移植后存活了至少四周。相对成熟的外节段仅在两只眼中发现，其中视网膜移植物形成玫瑰花状。

Photoreceptors from normal neonatal or transgenic neonatal mice with normally daveloping retinas were transplanted into the subretinal spaces of normal rats. The animals with transplants received either immunosuppressive treatment with tacrolimus hydrate (FK506) for the first two weeks after transplantation or no treatment. At four weeks after transplantation, graft survival occurred only in rats treated with tacrolimus. In 7 of the 12 treated eyes, photoreceptors survived at least four weeks after transplantation. Relatively mature outer segments were found only in two eyes in which the retinal grafts formed rosettes.