Development of A Next Generation Injector by Near IR Video-Bioanalysis

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1. Analyses of the needle injection into the skin by near IRvideo-scopeCurrent shape of the injection needles was investigated and the process of injection of the needle into the skin was analyzed by image analysis using near IR video-scope. It was found that the needle top of the injector cut off the skin in flat way and then the tube of the needle go into this space which will make pain.2. Analysis of silicon oil attachment on to the skin by observation of video-mass scope.Video-mass scope was developed and it was applied to investigate the attachment of silicon oil onto the skin where the needle was injected. The silicon oil which was coated on the needle of the injector, was transferred onto the injection point of the skin and stayed there even after the taking out.3. The analysis of injection wound recovery using a time lapse video-scope methodThe process of the recovery of injection wound was investigated using model cell layer of confluent 3T3 cells. Time lapse video scope showed that the recovery was accelerated by the presence of inside components of mast cell which was destroyed by the injection of the needle through the skin layer.4. Laser processing of the needle top using Nd : YAG laserA Nd : YAG laser was found to be used to make the surface of the needle top to be smooth in order to decrease the pain on insertion of the needle and also used to make the hole in the top.5. Development of the next generation injector and patent authorizationBased on these results, some types of the next generation injectors were proposed and be applied for patents. 1) the processing of the top sharp which will make less-painful injection, 2) the smoothing of the internal face of the needle top to make less pain, 3) oval shape needle to make less pain, 4) the needle with pain scattering ring or adaptor, 5) small needle with separated blood vacuum correction tube, and these idea were applied for patents.