Single-cell on-time molecular analysis by hyper-sensitive video-mass scope
Single-cell on-time molecular analysis by hyper-sensitive video-mass scope
批准号:
20229003
负责人:
MASUJIMA Tsutomu
金额:
$133.7万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011
中文摘要
我们在世界上首次建立了“活单细胞质谱法”,从活单细胞的兴趣点提取微量组分的分子,在显微镜观察下,10分钟内就可以进行彻底的、直接的分析。在肥大细胞细胞质和细胞器中的分子分布和代谢、分化的神经元细胞的分子交换、植物细胞的分子生物合成和光响应、单个肝细胞的药物代谢,甚至单个汗腺一滴中的分子含量都已被成功分析,显示了这种新的做梦方法的成果和潜力。
英文摘要
We have established“the live single cell mass spectrometry”first in the world by which molecules in a micro-sucked components from interest points of a live single cell can be analyzed exhaustively and directly under microscopic observation within 10 min. Molecular distribution and metabolism in cytoplasm and organelle in a live mast cell, molecular interchanging of differentiating neuron cell, molecular biosynthesis and photo response of live plant cells, drug metabolism of a single hepatic cell, and even molecular contents in only one drop from a single sweat gland have all been analyzed successfully to show the fruitful performance and potential of this new dreaming method.
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DOI:
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发表时间:
2009
期刊:
影响因子:
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作者:
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发表时间:
2011
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发表时间:
2011
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影响因子:
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Live single cell drug metabolism of tamoxifen analyzed by nano ESI mass spectrometry
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发表时间:
2009
期刊:
影响因子:
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[伊達沙智子, 他]
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使用视频质量范围法搜索细胞周期特异性分子指标
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发表时间:
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影响因子:
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共 217 条
Development of Dual-Tandem-Mass Spectrometer with a New Ion-trap and Its Application to Analysis of Molecular Nano-dynamics of a Cell
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批准号:18390014
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.27万
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财政年份:2006
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负责人:MASUJIMA Tsutomu
-
依托单位:
Establishment of Post-Proteomic Analysis by the Development of Video-Mass-Scope Method
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批准号:13470479
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2001
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of A Next Generation Injector by Near IR Video-Bioanalysis
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批准号:11794033
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项目类别:Grant-in-Aid for University and Society Collaboration
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资助金额:$4.61万
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财政年份:1999
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of A Chromato-video Spectro-Nanoscope and Establishment of Zeptmol Separation Base
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批准号:09554051
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.06万
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财政年份:1997
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of A Fiber Nano-scope with Molecular Trapping and its Application to the Analysis of Molecular Mechanism of Allergy
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批准号:09470495
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.64万
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财政年份:1997
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of Video Nanoscopes Using Crossed Laser Beams for Tracing of Drug Molecules
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批准号:07557295
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$1.34万
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财政年份:1995
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of Capillary Electrophoresis under Crossed Super Magnetic Field
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批准号:06452377
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.03万
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财政年份:1994
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of Nano-space Video Microscopy and its Application to the Analysis of New Pharmacological Dyanamics
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批准号:05557101
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$7.1万
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财政年份:1993
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of X-ray-and Chemi-luminescence Video-Microscopy and its Application to the Analysis of Biodynamics in Micro Region
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批准号:04454525
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.78万
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财政年份:1992
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of X-ray Acoustic Spectrometer Using Synchrotron Radiation
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批准号:02505001
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项目类别:Grant-in-Aid for Developmental Scientific Research (A)
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资助金额:$23.68万
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财政年份:1990
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of X-ray, Laser Photoacoustic Microscopy and Microanalysis
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批准号:02454480
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.1万
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财政年份:1990
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of X-ray Photoacoustic System for Brilliant Synchrotron Radiation and Analysis for New Materials
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批准号:01044098
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$1.54万
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财政年份:1989
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of X-ray photoacoustic spectroscopy and application to biological analysis
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批准号:62570968
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1987
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负责人:MASUJIMA Tsutomu
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依托单位:
Development of Laser Photoacoustic Imaging Immunoassay Metchod and System
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批准号:61870092
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$2.43万
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财政年份:1986
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负责人:MASUJIMA Tsutomu
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依托单位:
Analysis in Microregion by Fourier Transform Infrared/ Photoacoustic Microscopy
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批准号:60571019
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.96万
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财政年份:1985
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负责人:MASUJIMA Tsutomu
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依托单位:
海外基金