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Organization of Corticostriatal Inputs from Presupplementary and Cingulate Motor Areas

来自前补充和扣带运动区的皮质纹状体输入的组织

基本信息

批准号：
11680747
负责人：
TAKADA Masahiko
金额：
$ 2.18万
依托单位：
Tokyo Metropolitan Organization for Medical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680747/
关键词：
Basal ganglia Striatum Subthalamic nucleus Cerebral cortex Presupplementary motor area Primary motor cortex Motor control Cingulate motor area サル

项目摘要

The cingulate motor areas reside within regions lining the cingulate sulcus and are divided into rostral and caudal parts (CMAr and CMAc). Recent electrophysiological and functional imaging studies indicate that the CMAr and CMAc are involved in distinct aspects of motor function : The former plays a role in higher-order control, whereas the latter provides an executive role. Employing double/triple anterograde axonal tracing, we investigated the organization of inputs from the CMAr and CMAc to the basal ganglia in the macaque monkey. Identified forelimb representations of the CMAr and CMAc, as well as those of the supplementary and presupplementary motor areas and the primary motor cortex, were injected with different tracers, and spatial patterns of terminal label distributions were analyzed in the striatum and the subthalamic nucleus that constitute the major input stations of the basal ganglia. Corticostriatal terminals from the CMAr and CMAc were located within the rostral striatum, with the highest density in the striatal cell bridges or the ventrolateral portion of the putamen, respectively, and displayed no substantial overlap between their distribution areas. Likewise, considerable segregation of corticosubthalamic terminal fields from the CMAr and CMAc occurred mediolaterally in the nucleus. Such corticostriatal and corticosubthalamic input zones from the CMAr or CMAc at least in part overlapped those from the presupplementary motor area or the primary motor cortex, respectively. The present data suggest that a parallel design may essentially underlie motor information processing in the cortico-basal ganglia loop arising from the CMAr and CMAc.

扣带运动区位于扣带沟的内衬区域内，并分为吻侧和尾侧部分（CMAr和CMAc）。最近的电生理学和功能成像研究表明，CMAr和CMAc参与运动功能的不同方面：前者在高阶控制中发挥作用，而后者提供执行作用。采用双重/三重顺行轴突追踪，我们调查的组织输入从CMAr和CMAc的基底神经节的猕猴。确定前肢代表的CMAr和CMAc，以及补充和presupplementary运动区和初级运动皮层，注射不同的示踪剂，和空间模式的终端标签分布进行了分析，在纹状体和丘脑底核，构成基底神经节的主要输入站。CMAr和CMAc的皮质纹状体终末位于头侧纹状体内，密度最高的纹状体细胞桥或壳核的腹外侧部分，分别显示它们的分布区域之间没有实质性的重叠。同样，相当大的隔离皮质底丘脑终末领域的CMAr和CMAc发生mediolatively在核。这样的皮质纹状体和皮质丘脑底输入区从CMAr或CMAc至少部分重叠的presupplementary运动区或初级运动皮层，分别。目前的数据表明，一个平行的设计可能基本上是运动信息处理的皮质基底神经节回路所产生的CMAr和CMAc。