Functional neuroanatomy of masticatory control : Projections from cortical masticatory areas to basal ganglia

咀嚼控制的功能神经解剖学：从皮质咀嚼区到基底神经节的投射

• 批准号: 09832003
• 负责人: TAKADA Masahiko
• 金额: $ 1.86万
• 依托单位: Tokyo Metropolitan Institute for Neuroscience (1998)Kyoto University (1997)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09832003/
• 关键词: Mastication; Cerebral cortex; Primary motor cortex; Supplementary motor area; Basal ganglia; Reticular formation; Premotor neuron; Trigeminal motor neuron; 外側被蓋野; サル

We investigated the organization of parallel pathways connecting multiple jaw movement-related areas of the frontal lobe and the premotor neuron pool for the trigeminal motor nucleus (Vm) in the monkey. Our intracortical microstimulation mapping has revealed the existence of the following three cortical areas of which stimulation evokes jaw movements : the orofacial region of the primary motor cortex, the orofacial region of the supplementary motor area and the principal part of the cortical masticatory area. These jaw movement-related areas send projections not only directly to the lateral tegmental field-the major site of Vm premotor neurons-with the highest density in the regions surrounding the Vm, but also indirectly via the basal ganglia. In the basal ganglia, the ventral aspect of the putamen receives corticostriatal inputs from the jaw movement-related areas and, in turn, sends striatopallidal and striatonigral outputs to the ventral aspect of the internal segment of the globus pallidus or to the dorsal aspect of the substantia nigra pars reticulata, respectively. Then, direct projections from the globus pallidus and the substantia nigra terminate in the lateral tegmental field. Such parallel pathways may exert differential modulatory effects on the Vm via the premotor neurons.

我们研究了连接猴额叶多个颌部运动相关区域和三叉神经运动核（Vm）运动前神经元池的平行通路的组织。我们的皮层内微刺激图谱揭示了以下三个皮层区域的存在：初级运动皮层的口面区、辅助运动区的口面区和皮层咀嚼区的主体部分。这些与下颌运动相关的区域不仅直接向外侧被盖区（Vm周围区域密度最高的Vm前运动神经元的主要部位）发送投射，而且还间接通过基底神经节发送投射。在基底节区，壳核的腹侧接收来自下颌运动相关区域的皮质纹状体输入，并依次将纹状体和纹状体输出分别发送到苍白球内段的腹侧或网状黑质的背侧。然后，来自苍白球和黑质的直接投射终止于外侧被盖野。这种平行通路可能通过前运动神经元对Vm施加不同的调节作用。

项目成果

Takada M: "Corticostriatal input zones from the supplementary motor area overlap those from the contra-rather than ipsilateral primary motor cortex." Brain Res.791. 335-340 (1998)

Takada M：“辅助运动区的皮质纹状体输入区与对侧初级运动皮层的输入区重叠，而不是同侧初级运动皮层的输入区。”

Takada M: "Corticostriatal projections from the somatic motor areas of the frontal cortex in the macaque monkey : segregation versus overlap of input zones from the primary motor cortex, the supplementary motor area, and the premotor cortex." Exp Brain Re

Takada M：“猕猴额叶皮层体细胞运动区的皮质纹状体投射：初级运动皮层、辅助运动区和前运动皮层输入区的分离与重叠。”

Takada et al.: "Corticostriatal projections from the somatic motor areas of the frontal...." Experimental Brain Research. 120. 114-128 (1998)

Takada 等人：“额叶躯体运动区的皮质纹状体投射......”实验性大脑研究。

Kojima et al.: "Excitotoxic lesions of the pedunculontive tegmental uncleus..." Neuroscience Letters. 226. 111-114 (1997)

小岛等人：“脚被盖叔叔的兴奋毒性病变......”神经科学快报。

Takada et al.: "Corticostriatal input zones from the supplementary motor..." Brain Research. (印刷中).

Takada 等人：“辅助运动的皮质纹状体输入区……”大脑研究（正在出版）。