IMAGING OF AVASCULAR NECROSIS OF FEMORAL HEAD IN SPONTANEOUS HYPERTENSIVE RATS AND ITS EXPERIMENTAL MODEL

我们最初的目的是获得自发性高血压大鼠股骨头缺血性坏死的磁共振图像，但由于其直径太小，如2mm，我们未能成像。因此，我们改变了我们的计划，试图利用显微计算机断层扫描获得自发性高血压大鼠股骨头小梁结构的三维分析。我们获得了一些小梁结构分析的结果，但不幸的是，它们没有进一步研究的希望。我们再次改变了我们的计划，并尝试使用多探测器CT的数据对人体椎体小梁结构进行体内三维分析。我们利用微型CT内置的小梁结构三维分析软件，成功读取了多探测器CT的图像数据。我们利用一具人体尸体的椎体进行了三维分析的精度研究。我们评估了骨体积（BV）、骨表面（BS）、骨密度（BV/TV）、骨小梁厚度（Tb）的三维参数。Th)，小梁间隙(Tb。Sp)、骨小梁因子（TBPf）、结构模型指数（SMI）、淋巴结数（N. Nd）。我们测量了5次标本并计算了变异系数（CV）。BV， BS, BV/TV， Tb的简历。Th,结核病。Sp、TBPf、SMI、N. Nd分别为1.8%、0.91%、1.8%、1.4%、1.5%、7.7%、0.81%、2.5%。结果与双x线骨密度测量的精度相当。提示，骨小梁结构的体内三维分析可用于临床评价骨质疏松药物对骨小梁结构的影响。

We originally aimed to obtain magnetic resonance images of avascular necrosis of femoral head in spontaneous hypertensive rats, however, we failed to image them due to too small size of them such as 2mm in a diameter. Therefore, we change our plan and tried to obtain 3 dimensional analysis of trabecular structure of the femoral heads in spontaneous hypertensive rats using micro computed tomography. We obtained some results for the trabecular structural analysis, but, unfortunately, they were not promising of further study. We, again, changed our plan and tried to perform in vivo three-dimensional analysis of trabecular structure of human vertebra using data from multi-detector CT. We successfully read image data of multi-detector CT using the software for three-dimensional analysis of trabecular structure built in the micro CT. We performed precision study for the three-dimensional analysis using vertebra of a human cadaver. We evaluated three dimensional parameters of bone volume (BV) , bone surface (BS), bone density (BV/TV), trabecular thickness (Tb. Th), trabecular space (Tb. Sp), trabecular bone factor (TBPf) , structure model index (SMI) , number of nodes (N. Nd). We measured the specimens five times and calculated coefficient variation (CV). The CVs in BV, BS, BV/TV, Tb. Th, Tb. Sp, TBPf, SMI, N. Nd were 1.8 %, 0.91 %, 1.8 %, 1.4 %, 1.5 %, 7.7 %, 0.81 %, 2.5 %, respectively. The results were comparable to the precision of bone densitometry by dual x-ray absorptiometry. This suggest that in vivo three dimensional analysis of trabecular bone structure would be used clinically for evaluating effects of drugs for osteoporosis on trabecular bone structure.