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Three-dimensional analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography-cross sectional and longitudinal studies-

使用多探测器行计算机断层扫描对体内人体椎骨骨小梁结构进行三维分析-横断面和纵向研究-

基本信息

批准号：
14570852
负责人：
TAKADA Masahiko
金额：
$ 1.15万
依托单位：
Shiga University of Medical Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

项目摘要

We developed a system to perform three-dimensional(3D) analysis of trabecular bone structure of human vertebra in vivo using multi-detector row computed tomography(MDCT). The purpos was to evaluate whether 3D structural parameters can evaluate fragility of bone. We studied 20 women with no vertebral fractures(67±8 years old) and 27 women with vertebral fractures(74±7 years old). They underwent lumbar examinations by MDCT and dual x-ray absorptiometry(DXA). The' following 3D parameters were calculated ; trabecular bone volume fraction(BV/TV), trabecular thickness(Tb.Th), trabecular number(Tb.N), trabecular separation(Tb.Sp), trabecular bone pattern factor(TBPf), structure model index(SMI), and Fractal dimension(FD). Correlation between structural parameters and BMD was evaluated by linear regression analysis, and discrimination between women with and without vertebral fractures was evaluated by student t' test. The BMD was significantly correlated with the values of BV/TV,.Tb.Sp, TBPf, SMI and FD with correlation coefficients of 0.30,0.32,-0.46,-0.44 and 0.36,respectively. The values of TBPf, SMI and FD significantly differed between the two groups with t-values of 2.6,3.2,and 2.4,respectively, but the L3 BMD did not differ. The results suggested that trabecular bone structure correlated with BMD and that the trabecular bone structural analysis could evaluate bone fragility cross-sectionlay. We evaluated the same subjects londitudinaly for four years, but these parameters did not change significantly.

我们开发了一个系统，使用多探测器行计算机断层扫描（MDCT）进行三维（3D）分析的人体椎体骨小梁结构在体内。目的：探讨三维结构参数能否评价骨的脆性。我们研究了20名无椎骨骨折的女性（67±8岁）和27名椎骨骨折的女性（74±7岁）。他们通过MDCT和双能X线吸收法（DXA）进行腰椎检查。计算以下三维参数：骨小梁体积分数（BV/TV）、骨小梁厚度（Tb.Th）、骨小梁数量（Tb.N）、骨小梁间隔（Tb.Sp）、骨小梁模式因子（TBPF）、结构模型指数（SMI）和分形维数（FD）。用线性回归分析评价结构参数与骨密度的相关性，用t检验评价有无椎骨骨折妇女之间的区分度。BMD与BV/TV、Tb、Sp、TBPF、SMI和FD呈显著正相关，相关系数分别为0.30、0.32、-0.46、-0.44和0.36。TBPf、SMI和FD在两组间差异有统计学意义（t值分别为2.6、3.2和2.4），但L3 BMD无差异。结果表明，骨小梁结构与骨密度相关，骨小梁结构分析可以评价骨脆性截面积。我们对相同的受试者进行了四年的纵向评估，但这些参数没有显著变化。